概述

产品描述	Rabbit Polyclonal antibody recognizes Caspase 2
反应物种	Hu, Ms, Rat
应用	WB
宿主	Rabbit
克隆	Polyclonal
同位型	IgG
靶点名称	Caspase 2
抗原物种	Human
抗原	Synthetic peptide of Human Caspase 2.
偶联标记	Un-conjugated
別名	Protease ICH-1; PPP1R57; NEDD-2; EC 3.4.22.55; NEDD2; Caspase-2; CASP-2; ICH1; Neural precursor cell expressed developmentally down-regulated protein 2

应用说明

应用建议	应用 推荐稀释比 WB 1:500 - 1:1000
应用说明	* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
阳性对照	HeLa
实际分子量	~ 48 kDa (uncleaved); ~ 32 kDa (cleaved)

属性

形式	Liquid
纯化	Affinity purified.
缓冲液	PBS (pH 7.4), 150 mM NaCl, 0.02% Sodium azide and 50% Glycerol.
抗菌剂	0.02% Sodium azide
稳定剂	50% Glycerol
存放说明	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 12366 Mouse CASP2 GeneID: 64314 Rat CASP2 GeneID: 835 Human CASP2 Swiss-port # P29594 Mouse Caspase-2 Swiss-port # P42575 Human Caspase-2 Swiss-port # P55215 Rat Caspase-2 More
基因名称	CASP2
全名	caspase 2, apoptosis-related cysteine peptidase
背景介绍	This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Caspases mediate cellular apoptosis through the proteolytic cleavage of specific protein substrates. The encoded protein may function in stress-induced cell death pathways, cell cycle maintenance, and the suppression of tumorigenesis. Increased expression of this gene may play a role in neurodegenerative disorders including Alzheimer's disease, Huntington's disease and temporal lobe epilepsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
生物功能	Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival. [UniProt]
预测分子量	51 kDa (uncleaved)
翻译后修饰	The mature protease can process its own propeptide, but not that of other caspases. [UniProt]

检测图片 (1) Click the Picture to Zoom In