ARG42692
anti-Carboxypeptidase B2 antibody
anti-Carboxypeptidase B2 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes Carboxypeptidase B2 |
|---|---|
| 反应物种 | Hu |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | Carboxypeptidase B2 |
| 抗原物种 | Human |
| 抗原 | Recombinant protein corresponding to K166-D388 of Human Carboxypeptidase B2. |
| 偶联标记 | Un-conjugated |
| 別名 | Plasma carboxypeptidase B; Thrombin-activable fibrinolysis inhibitor; PCPB; Carboxypeptidase B2; TAFI; pCPB; EC 3.4.17.20; CPU; Carboxypeptidase U |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | 0.2% Na2HPO4, 0.9% NaCl, 0.05% Sodium azide and 5% BSA. |
| 抗菌剂 | 0.05% Sodium azide |
| 稳定剂 | 5% BSA |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | CPB2 |
| 全名 | carboxypeptidase B2 (plasma) |
| 背景介绍 | Carboxypeptidases are enzymes that hydrolyze C-terminal peptide bonds. The carboxypeptidase family includes metallo-, serine, and cysteine carboxypeptidases. According to their substrate specificity, these enzymes are referred to as carboxypeptidase A (cleaving aliphatic residues) or carboxypeptidase B (cleaving basic amino residues). The protein encoded by this gene is activated by trypsin and acts on carboxypeptidase B substrates. After thrombin activation, the mature protein downregulates fibrinolysis. Polymorphisms have been described for this gene and its promoter region. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013] |
| 生物功能 | Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down-regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin. [UniProt] |
| 细胞定位 | Secreted. [UniProt] |
| 预测分子量 | 48 kDa |
| 翻译后修饰 | N-glycosylated. N-glycan at Asn-108: Hex5HexNAc4. [UniProt] |
检测图片 (2) Click the Picture to Zoom In
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ARG42692 anti-Carboxypeptidase B2 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human lung cancer tissue stained with ARG42692 anti-Carboxypeptidase B2 antibody at 1 µg/ml dilution.
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ARG42692 anti-Carboxypeptidase B2 antibody WB image
Western blot: Human placenta and HepG2 whole cell lysates stained with ARG42692 anti-Carboxypeptidase B2 antibody at 0.5 µg/ml dilution.
