ARG40325
anti-Calpain 2 antibody
anti-Calpain 2 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes Calpain 2 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | Calpain 2 |
| 抗原物种 | Human |
| 抗原 | Recombinant fusion protein corresponding to aa. 350-680 of Human Calpain 2 (NP_001739.2). |
| 偶联标记 | Un-conjugated |
| 別名 | CANP2; Calpain-2 large subunit; Calpain-2 catalytic subunit; EC 3.4.22.53; Millimolar-calpain; M-calpain; mCANP; Calpain large polypeptide L2; Calpain M-type; CANP 2; CANPL2; CANPml; Calcium-activated neutral proteinase 2 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | Mouse kidney and H460 | ||||||
| 实际分子量 | ~ 80 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | CAPN2 |
| 全名 | calpain 2, (m/II) large subunit |
| 背景介绍 | The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 2. Multiple heterogeneous transcriptional start sites in the 5' UTR have been reported. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009] |
| 生物功能 | Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226'. [UniProt] |
| 细胞定位 | Cytoplasm. Cell membrane. Note=Translocates to the plasma membrane upon Ca(2+) binding. [UniProt] |
| 预测分子量 | 80 kDa |
检测图片 (2) Click the Picture to Zoom In
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ARG40325 anti-Calpain 2 antibody WB image
Western blot: 25 µg of H460 cell lysate stained with ARG40325 anti-Calpain 2 antibody at 1:1000 dilution.
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ARG40325 anti-Calpain 2 antibody WB image
Western blot: 25 µg of Mouse kidney lysate stained with ARG40325 anti-Calpain 2 antibody at 1:1000 dilution.
