ARG23191
anti-Calcitonin Receptor antibody [31/01-1H10-4-1-14]
anti-Calcitonin Receptor antibody [31/01-1H10-4-1-14] for ELISA,Flow cytometry,ICC/IF,IHC-Frozen sections,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Rabbit
概述
| 产品描述 | Mouse Monoclonal antibody [31/01-1H10-4-1-14] recognizes Calcitonin Receptor Mouse anti Human calcitonin recptor antibody, clone 31/01-1H10-4-1-14 recognizes the human calcitonin receptor, a membrane protein with seven transmembrane domains that is coupled to G protein messenger systems. Mouse anti Human calcitonin recptor antibody, clone 31/01-1H10-4-1-14 recognizes an epitope within the cytoplasmic domain that is common to both C1a and C1b human isoforms. Calcitonin receptor is expressed in kidney, central and peripheral nervous systems and on osteoclasts. It is also expressed in a number of tissues during the development of the embryo and may be important in foetal morphogenesis. |
|---|---|
| 反应物种 | Hu, Rb |
| 应用 | ELISA, FACS, ICC/IF, IHC-Fr, IHC-P, WB |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | 31/01-1H10-4-1-14 |
| 同位型 | IgG2a |
| 靶点名称 | Calcitonin Receptor |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide around the cytoplasmic domain of Human calcitonin receptor. (DIPIYICHQELRNEPANN) |
| 偶联标记 | Un-conjugated |
| 別名 | CT-R; CTR1; CTR; CRT; Calcitonin receptor |
应用说明
| 应用建议 |
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| 应用说明 | IHC-P: Fixation with 4% paraformaldehyde is recommended for optimal results. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein A. |
| 缓冲液 | PBS and 0.09% Sodium azide. |
| 抗菌剂 | 0.09% Sodium azide |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | CALCR |
| 全名 | calcitonin receptor |
| 背景介绍 | This gene encodes a high affinity receptor for the peptide hormone calcitonin and belongs to a subfamily of seven transmembrane-spanning G protein-coupled receptors. The encoded protein is involved in maintaining calcium homeostasis and in regulating osteoclast-mediated bone resorption. Polymorphisms in this gene have been associated with variations in bone mineral density and onset of osteoporosis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009] |
| 生物功能 | This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin. [UniProt] |
| 预测分子量 | 55 kDa |
