ARG67269
anti-Cadherin (pan) antibody [SQab30385]
anti-Cadherin (pan) antibody [SQab30385] for IHC-Formalin-fixed paraffin-embedded sections and Human
概述
| 产品描述 | Rabbit Monoclonal antibody [SQab30385] recognizes Cadherin (pan). |
|---|---|
| 反应物种 | Hu |
| 应用 | IHC-P |
| 宿主 | Rabbit |
| 克隆 | Monoclonal |
| 克隆号 | SQab30385 |
| 同位型 | IgG |
| 靶点名称 | Cadherin (pan) |
| 抗原 | Synthetic peptide. |
| 偶联标记 | Un-conjugated |
| 別名 | CDH1; Cadherin 1; Uvomorulin; CD324; UVO; Cadherin 1, Type 1, E-Cadherin (Epithelial); Epithelial Cadherin; E-Cadherin; Cadherin-1; CAM 120/80; CDHE; Calcium-Dependent Adhesion Protein, Epithelial; Epididymis Secretory Sperm Binding Protein; Cadherin 1, E-Cadherin (Epithelial); Cell-CAM 120/80; CD324 Antigen; E-Cadherin 1; Arc-1; BCDS1; ECAD; LCAM |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | PBS, 0.01% Sodium azide, 40% Glycerol and 0.05% BSA. |
| 抗菌剂 | 0.01% Sodium azide |
| 稳定剂 | 40% Glycerol and 0.05% BSA |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | CDH1 |
| 全名 | Cadherin 1 |
| 背景介绍 | This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16. [provided by RefSeq, Nov 2015] |
| 生物功能 | Serves as a receptor for Listeria monocytogenes; internalin A (InlA) binds to this protein and promotes uptake of the bacteria. [Uniprot] |
| 细胞定位 | Cell junction, Cell membrane, Cytoplasm, Endosome, Golgi apparatus, Membrane. [Uniprot] |
| 预测分子量 | 97 kDa |
| 翻译后修饰 | Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugation. [Uniprot] |
检测图片 (1) Click the Picture to Zoom In
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ARG67269 anti-Cadherin (pan) antibody [SQab30385] IHC-P image
Immunohistochemistry: Human Esophagus stained with ARG67269 anti-Cadherin (pan) antibody [SQab30385] at 1:100 dilution.
