ARG58074
anti-CaSR / Calcium Sensing Receptor antibody
anti-CaSR / Calcium Sensing Receptor antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes CaSR / Calcium Sensing Receptor |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | CaSR / Calcium Sensing Receptor |
| 抗原物种 | Human |
| 抗原 | Recombinant fusion protein corresponding to aa. 874-1088 of Human CaSR (NP_001171536.1). |
| 偶联标记 | Un-conjugated |
| 別名 | Extracellular calcium-sensing receptor; EIG8; FHH; PCaR1; CAR; HHC1; GPRC2A; Parathyroid cell calcium-sensing receptor 1; HHC; PCAR1; CaSR; HYPOC1; FIH; NSHPT |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | SH-SY5Y |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | CASR |
| 全名 | calcium-sensing receptor |
| 背景介绍 | The protein encoded by this gene is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule. It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism. [provided by RefSeq, Jul 2008] |
| 生物功能 | Senses changes in the extracellular concentration of calcium ions. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. [UniProt] |
| 细胞定位 | Cell membrane, Multi-pass membrane protein. [UniProt] |
| 预测分子量 | 121 kDa |
| 翻译后修饰 | N-glycosylated. Ubiquitinated by RNF19A; which induces proteasomal degradation. [UniProt] |
检测图片 (1) Click the Picture to Zoom In
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ARG58074 anti-CaSR / Calcium Sensing Receptor antibody WB image
Western blot: 25 µg of SH-SY5Y cell lysate stained with ARG58074 anti-CaSR / Calcium Sensing Receptor antibody at 1:1000 dilution.
