ARG44590
anti-CYP3A4 antibody
anti-CYP3A4 antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes CYP3A4 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | ICC/IF, IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | CYP3A4 |
| 抗原物种 | Human |
| 抗原 | Recombinant protein of human CYP3A4 (a.a. 244-503). |
| 偶联标记 | Un-conjugated |
| 別名 | CYP3A4; Cytochrome P450 Family 3 Subfamily A Member 4; CYP3A3; Cytochrome P450, Subfamily IIIA (Niphedipine Oxidase), Polypeptide 4; Cytochrome P450, Family 3, Subfamily A, Polypeptide 4; Albendazole Monooxygenase (Sulfoxide-Forming); 1,4-Cineole 2-Exo-Monooxygenase; 1,8-Cineole 2-Exo-Monooxygenase; Cholesterol 25-Hydroxylase; Albendazole Sulfoxidase; Quinine 3-Monooxygenase; Cytochrome P450 NF-25; Cytochrome P450-PCN1; Cytochrome P450 3A4; Cytochrome P450 3A3; Cytochrome P450 HLp; Nifedipine Oxidase; EC 1.14.14.1; CYPIIIA3; CYPIIIA4; Cytochrome P450, Subfamily IIIA (Niphedipine Oxidase), Polypeptide 3; Taurochenodeoxycholate 6-Alpha-Hydroxylase; Glucocorticoid-Inducible P450; P450-III, Steroid Inducible; EC 1.14.14.56; EC 1.14.14.73; EC 1.14.14.55; P450PCN1; P450C3; CYP3A; NF-25; VDDR3; CP33; CP34; HLP |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | CYP3A4 |
| 全名 | Cytochrome P450 Family 3 Subfamily A Member 4 |
| 背景介绍 | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam, erythromycin, and chloroquine. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2020] |
| 生物功能 | Also involved in vitamin D catabolism and calcium homeostasis. Catalyzes the inactivation of the active hormone calcitriol (1-alpha,25-dihydroxyvitamin D3).[UniProt] |
| 细胞定位 | Endoplasmic reticulum, Membrane, Microsome.[UniProt] |
| 预测分子量 | 57 kDa |
| 翻译后修饰 | Ubl conjugation |
检测图片 (4) Click the Picture to Zoom In
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ARG44590 anti-CYP3A4 antibody ICC/IF image
Immunofluorescence: HeLa stained with ARG44590 anti-CYP3A4 antibody at 1:100 dilution.
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ARG44590 anti-CYP3A4 antibody WB image
Western blot: 293F cells transfected with CYP3A4 stained with ARG44590 anti-CYP3A4 antibody at 1:1000 dilution.
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ARG44590 anti-CYP3A4 antibody IHC-P image
Immunohistochemistry: Rat ovary stained with ARG44590 anti-CYP3A4 antibody at 1:100 dilution.
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ARG44590 anti-CYP3A4 antibody IHC-P image
Immunohistochemistry: Mouse liver stained with ARG44590 anti-CYP3A4 antibody at 1:100 dilution.
