ARG44589
anti-CYP2D6 antibody
anti-CYP2D6 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes CYP2D6 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | CYP2D6 |
| 抗原物种 | Human |
| 抗原 | A synthetic peptide of human CYP2D6. |
| 偶联标记 | Un-conjugated |
| 別名 | CYP2D6; Cytochrome P450 Family 2 Subfamily D Member 6; P450-DB1 P450C2D; CYP2DL1; CYP2D; CPD6; Cytochrome P450, Subfamily IID (Debrisoquine, Sparteine, Etc., -Metabolising), Polypeptide 8 Pseudogene 2; Cytochrome P450, Subfamily II (Debrisoquine, Sparteine, Etc., -Metabolising), Polypeptide 7 Pseudogene 2; Cytochrome P450, Subfamily IID (Debrisoquine, Sparteine, Etc., -Metabolizing), Polypeptide 6; Cytochrome P450, Family 2, Subfamily D, Polypeptide 7 Pseudogene 2; Cytochrome P450, Family 2, Subfamily D, Polypeptide 8 Pseudogene 2; Cytochrome P450, Family 2, Subfamily D, Polypeptide 6; Cholesterol 25-Hydroxylase; Debrisoquine 4-Hydroxylase; Cytochrome P450 2D6; Cytochrome P450-DB1; CYP2D7AP; CYP2D7BP; CYP2D7P2; CYP2D8P2; CYPIID6; Cytochrome P450, Subfamily IID (Debrisoquine, Sparteine, Etc., -Metabolizing)-Like 1; Flavoprotein-Linked Monooxygenase; Nonfunctional Cytochrome P450 2D6; Microsomal Monooxygenase; Xenobiotic Monooxygenase; EC 1.14.14.; EC 1.14.14.1; P450DB1 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | 0.2% Na2HPO4, 0.9% NaCl, 0.05% Sodium azide and 4% Trehalose. |
| 抗菌剂 | 0.05% Sodium azide |
| 稳定剂 | 4% Trehalose |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | CYP2D6 |
| 全名 | Cytochrome P450 Family 2 Subfamily D Member 6 |
| 背景介绍 | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 25% of commonly prescribed drugs. Its substrates include antidepressants, antipsychotics, analgesics and antitussives, beta adrenergic blocking agents, antiarrythmics and antiemetics. The gene is highly polymorphic in the human population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. Some individuals with the poor metabolizer phenotype have no functional protein since they carry 2 null alleles whereas in other individuals the gene is absent. This gene can vary in copy number and individuals with the ultrarapid metabolizer phenotype can have 3 or more active copies of the gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014] |
| 生物功能 | Catalyzes the oxidative transformations of all-trans retinol to all-trans retinal, a precursor for the active form all-trans-retinoic acid. Also involved in the oxidative metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.[UniProt] |
| 细胞定位 | Endoplasmic reticulum, Membrane, Microsome.[UniProt] |
| 预测分子量 | 56 kDa |
检测图片 (4) Click the Picture to Zoom In
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ARG44589 anti-CYP2D6 antibody IHC-P image
Immunohistochemistry: Human liver stained with ARG44589 anti-CYP2D6 antibody at 1μg/ml dilution.
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ARG44589 anti-CYP2D6 antibody WB image
Western blot: Rat liver and Mouse liver stained with ARG44589 anti-CYP2D6 antibody at 0.5 μg/mL dilution.
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ARG44589 anti-CYP2D6 antibody IHC-P image
Immunohistochemistry: Rat intestine stained with ARG44589 anti-CYP2D6 antibody at 1μg/ml dilution.
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ARG44589 anti-CYP2D6 antibody IHC-P image
Immunohistochemistry: Mouse intestine stained with ARG44589 anti-CYP2D6 antibody at 1μg/ml dilution.
