ARG41532
anti-CYP19A1 / Aromatase antibody
anti-CYP19A1 / Aromatase antibody for Immunoprecipitation,Western blot and Human,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes CYP19A1 / Aromatase |
|---|---|
| 反应物种 | Hu, Rat |
| 应用 | IP, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | CYP19A1 / Aromatase |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide of Human CYP19A1 / Aromatase. |
| 偶联标记 | Un-conjugated |
| 別名 | ARO1; CPV1; CYAR; Aromatase; Cytochrome P450 19A1; CYP19; Cytochrome P-450AROM; P-450AROM; Estrogen synthase; EC 1.14.14.14; CYPXIX; ARO |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | Rat brain | ||||||
| 实际分子量 | ~ 57 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.4), 150 mM NaCl, 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | CYP19A1 |
| 全名 | cytochrome P450, family 19, subfamily A, polypeptide 1 |
| 背景介绍 | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014] |
| 生物功能 | Catalyzes the formation of aromatic C18 estrogens from C19 androgens. [UniProt] |
| 细胞定位 | Membrane; Peripheral membrane protein. [UniProt] |
| 预测分子量 | 58 kDa |
| 翻译后修饰 | Phosphorylated in vitro by PKA and PKG/PRKG1. These phosphorylations inhibit the catalytic activity as measured by estrone synthesis from androstenedione (36% decrease for PKA and 30% for PKG/PRKG1). [UniProt] |
检测图片 (1) Click the Picture to Zoom In
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ARG41532 anti-CYP19A1 / Aromatase antibody WB image
Western blot: Rat brain lysate stained with ARG41532 anti-CYP19A1 / Aromatase antibody.
