ARG54363
anti-CX3CR1 (extracellular loop) antibody
anti-CX3CR1 (extracellular loop) antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
Cancer antibody; Controls and Markers antibody; Immune System antibody; Microbiology and Infectious Disease antibody; Neuroscience antibody
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes CX3CR1 (extracellular loop) |
|---|---|
| 反应物种 | Hu |
| 应用 | IHC-P, WB |
| 特异性 | This antibody recognizes human, mouse and rat CX3CR1 (50 kD). |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | CX3CR1 (extracellular loop) |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide corresponding to aa. 175-189 of Human CX3CR1. |
| 偶联标记 | Un-conjugated |
| 別名 | CMK-BRL1; GPR13; CX3CR1; CMK-BRL-1; C-X3-C CKR-1; CX3C chemokine receptor 1; V28; CCRL1; GPRV28; CMKBRL1; G-protein coupled receptor 13; CMKDR1; Beta chemokine receptor-like 1; Fractalkine receptor |
应用说明
| 应用建议 |
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| 应用说明 | Western blot: use at 1:500 dilution. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
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| 阳性对照 | THP-1 |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Immunoaffinity chroma-tography |
| 缓冲液 | PBS (pH 7.4) and 0.02% Sodium azide |
| 抗菌剂 | 0.02% Sodium azide |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | CX3CR1 |
| 全名 | chemokine (C-X3-C motif) receptor 1 |
| 背景介绍 | CX 3 CR1 is one of the chemokine receptors that are required as co-receptors for HIV infection. The genes encoding human, murine, and rat CX 3 CR1 have been cloned and designated V28 and CMKBRL1, CX 3 CR1, and RBS11, respectively. This transmembrane protein was recently identified as the receptor for a novel transmembrane molecule, fractalkine, and was renamed CX 3 CR1. Recently, CX 3 CR1was found to serve as a coreceptor for HIV-1 and HIV-2 envelope fusion and virus infection, which can be inhibited by factalkine. CX 3 CR1 mediates leukocyte migration and adhesion and is expressed in a variety of human tissues and cell lines. |
| 生物功能 | Receptor for the CX3C chemokine fractalkine and mediates both its adhesive and migratory functions. Acts as coreceptor with CD4 for HIV-1 virus envelope protein (in vitro). Isoform 2 and isoform 3 seem to be more potent HIV-1 coreceptors than isoform 1. [UniProt] |
| 研究领域 | Cancer antibody; Controls and Markers antibody; Immune System antibody; Microbiology and Infectious Disease antibody; Neuroscience antibody |
| 预测分子量 | 40 kDa |
| 翻译后修饰 | This protein is not N-glycosylated which is unusual for G-protein-coupled receptors. |
检测图片 (2) Click the Picture to Zoom In
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ARG54363 anti-CX3CR1 (extracellular loop) antibody IHC-P image
Immunohistochemistry: Human spleen stained with ARG54363 anti-CX3CR1 (extracellular loop) antibody at 10 μg/mL dilution.
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ARG54363 anti-CX3CR1 (extracellular loop) antibody WB image
Western blot: THP-1 stained with ARG54363 anti-CX3CR1 (extracellular loop) antibody at 1 μg/mL dilution.
