anti-CTH / Cystathionase antibody
anti-CTH / Cystathionase antibody for Western blot and Human,Mouse
|Rabbit Polyclonal antibody recognizes CTH / Cystathionase
|CTH / Cystathionase
|Recombinant fusion protein corresponding to aa. 1-405 of Human CTH / Cystathionase (NP_001893.2).
|EC 220.127.116.11; Cysteine-protein sulfhydrase; Gamma-cystathionase; Cystathionine gamma-lyase
|* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
|PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol.
|0.02% Sodium azide
|For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
|For laboratory research only, not for drug, diagnostic or other use.
|This gene encodes a cytoplasmic enzyme in the trans-sulfuration pathway that converts cystathione derived from methionine into cysteine. Glutathione synthesis in the liver is dependent upon the availability of cysteine. Mutations in this gene cause cystathioninuria. Alternative splicing of this gene results in three transcript variants encoding different isoforms. [provided by RefSeq, Jun 2010]
|Catalyzes the last step in the trans-sulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molecules to lanthionine and hydrogen sulfide. Can also accept homocysteine as substrate. Specificity depends on the levels of the endogenous substrates. Generates the endogenous signaling molecule hydrogen sulfide (H2S), and so contributes to the regulation of blood pressure. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration of target proteins: sulfhydration consists of converting -SH groups into -SSH on specific cysteine residues of target proteins such as GAPDH, PTPN1 and NF-kappa-B subunit RELA, thereby regulating their function. [UniProt]
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