ARG55220
anti-CTDSP1 antibody
anti-CTDSP1 antibody for Western blot and Human,Mouse
Gene Regulation antibody; Signaling Transduction antibody
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes CTDSP1 |
|---|---|
| 反应物种 | Hu, Ms |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | CTDSP1 |
| 抗原物种 | Human |
| 抗原 | KLH-conjugated synthetic peptide corresponding to aa. 16-50 (N-terminus) of Human CTDSP1. |
| 偶联标记 | Un-conjugated |
| 別名 | NLI-interacting factor 3; Small CTD phosphatase 1; Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1; NLIIF; Nuclear LIM interactor-interacting factor 3; EC 3.1.3.16; NLI-IF; NIF3; SCP1; Small C-terminal domain phosphatase 1 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 阳性对照 | HepG2 |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein A and immunogen peptide. |
| 缓冲液 | PBS and 0.09% (W/V) Sodium azide |
| 抗菌剂 | 0.09% (W/V) Sodium azide |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # P58466 Mouse Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase Swiss-port # Q9GZU7 Human Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase |
|---|---|
| 基因名称 | CTDSP1 |
| 全名 | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 |
| 背景介绍 | This gene encodes a member of the small C-terminal domain phosphatase (SCP) family of nuclear phosphatases. These proteins play a role in transcriptional regulation through specific dephosphorylation of phosphoserine 5 within tandem heptapeptide repeats of the C-terminal domain of RNA polymerase II. The encoded protein plays a role in neuronal gene silencing in non-neuronal cells, and may also inhibit osteoblast differentiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011] |
| 生物功能 | Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. [UniProt] |
| 细胞定位 | Nucleus. Note=Colocalizes with RNA polymerase II |
| 研究领域 | Gene Regulation antibody; Signaling Transduction antibody |
| 预测分子量 | 29 kDa |
检测图片 (1) Click the Picture to Zoom In
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ARG55220 anti-CTDSP1 antibody WB image
Western blot: 20 µg of HepG2 cell lysate stained with ARG55220 anti-CTDSP1 antibody at 1:1000 dilution.
