ARG52907
anti-CSF1R antibody [SP211]
anti-CSF1R antibody [SP211] for IHC-Formalin-fixed paraffin-embedded sections and Human
Cell Biology and Cellular Response antibody; Immune System antibody; Signaling Transduction antibody
概述
| 产品描述 | Rabbit Monoclonal antibody [SP211] recognizes CSF1R |
|---|---|
| 反应物种 | Hu |
| 应用 | IHC-P |
| 宿主 | Rabbit |
| 克隆 | Monoclonal |
| 克隆号 | SP211 |
| 同位型 | IgG |
| 靶点名称 | CSF1R |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide from human CSF-1R protein. |
| 偶联标记 | Un-conjugated |
| 別名 | CSF-1 receptor; CSF-1-R; FIM2; Macrophage colony-stimulating factor 1 receptor; Proto-oncogene c-Fms; CD115; CD antigen CD115; M-CSF-R; FMS; CSFR; C-FMS; EC 2.7.10.1; CSF-1R; HDLS |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 阳性对照 | Tonsil |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purified by protein A/G |
| 缓冲液 | PBS (pH 7.6), 1% BSA and < 0.1% Sodium azide |
| 抗菌剂 | < 0.1% Sodium azide |
| 稳定剂 | 1% BSA |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # P07333 Human Macrophage colony-stimulating factor 1 receptor |
|---|---|
| 背景介绍 | Colony stimulating factor 1 receptor (CSF1R), also known as macrophage colony-stimulating factor receptor and CD115, is a cell-surface tyrosine-protein kinase receptor for colony stimulating factor 1 (CSF1) and IL-34. It is expressed by monocytes and its progenitor or derived cells. It plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes. It is up-regulated in some human tumors such as carcinoma of ovary and breast. |
| 细胞定位 | Cytoplasm, Membrane, Nucleus (cleaved form) |
| 研究领域 | Cell Biology and Cellular Response antibody; Immune System antibody; Signaling Transduction antibody |
| 预测分子量 | 108 kDa |
| 翻译后修饰 | Autophosphorylated in response to CSF1 or IL34 binding. Phosphorylation at Tyr-561 is important for normal down-regulation of signaling by ubiquitination, internalization and degradation. Phosphorylation at Tyr-561 and Tyr-809 is important for interaction with SRC family members, including FYN, YES1 and SRC, and for subsequent activation of these protein kinases. Phosphorylation at Tyr-699 and Tyr-923 is important for interaction with GRB2. Phosphorylation at Tyr-723 is important for interaction with PIK3R1. Phosphorylation at Tyr-708 is important for normal receptor degradation. Phosphorylation at Tyr-723 and Tyr-809 is important for interaction with PLCG2. Phosphorylation at Tyr-969 is important for interaction with CBL. Dephosphorylation by PTPN2 negatively regulates downstream signaling and macrophage differentiation. Ubiquitinated. Becomes rapidly polyubiquitinated after autophosphorylation, leading to its degradation. |
检测图片 (6) Click the Picture to Zoom In
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ARG52907 anti-CSF1R antibody [SP211] IHC-P image
Immunohistochemistry: Human Tonsil stained with ARG52907 anti-CSF1R antibody [SP211].
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ARG52907 anti-CSF1R antibody [SP211] IHC-P image
Immunohistochemistry: Human Skin stained with ARG52907 anti-CSF1R antibody [SP211].
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ARG52907 anti-CSF1R antibody [SP211] IHC-P image
Immunohistochemistry: Human Skin Squamous Cell Carcinoma stained with ARG52907 anti-CSF1R antibody [SP211].
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ARG52907 anti-CSF1R antibody [SP211] IHC-P image
Immunohistochemistry: Human Colon stained with ARG52907 anti-CSF1R antibody [SP211].
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ARG52907 anti-CSF1R antibody [SP211] IHC-P image
Immunohistochemistry: Human lung stained with ARG52907 anti-CSF1R antibody [SP211].
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ARG52907 anti-CSF1R antibody [SP211] IHC-P image
Immunohistochemistry: Human liver stained with ARG52907 anti-CSF1R antibody [SP211].
