ARG42631
anti-CRMP1 antibody
anti-CRMP1 antibody for Flow cytometry,ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Immunoprecipitation,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes CRMP1 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | FACS, ICC/IF, IHC-P, IP, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | CRMP1 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide derived from Human CRMP1. |
| 偶联标记 | Un-conjugated |
| 別名 | Collapsin response mediator protein 1; DPYSL1; Dihydropyrimidinase-related protein 1; DRP1; DRP-1; ULIP-3; CRMP-1; Unc-33-like phosphoprotein 3 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||||||
| 阳性对照 | SH-SY5Y | ||||||||||||
| 实际分子量 | ~ 62 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.4), 150 mM NaCl, 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q14194 Human Dihydropyrimidinase-related protein 1 Swiss-port # Q62950 Rat Dihydropyrimidinase-related protein 1 |
|---|---|
| 基因名称 | CRMP1 |
| 全名 | collapsin response mediator protein 1 |
| 背景介绍 | This gene encodes a member of a family of cytosolic phosphoproteins expressed exclusively in the nervous system. The encoded protein is thought to be a part of the semaphorin signal transduction pathway implicated in semaphorin-induced growth cone collapse during neural development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008] |
| 生物功能 | Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton (PubMed:25358863). Plays a role in axon guidance (PubMed:25358863). During the axon guidance process, acts downstream of SEMA3A to promote FLNA dissociation from F-actin which results in the rearrangement of the actin cytoskeleton and the collapse of the growth cone (PubMed:25358863). Involved in invasive growth and cell migration (PubMed:11562390). May participate in cytokinesis (PubMed:19799413). [UniProt] |
| 细胞定位 | Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Associated with centrosomes and the mitotic spindle during metaphase. [UniProt] |
| 预测分子量 | 62 kDa |
检测图片 (1) Click the Picture to Zoom In
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ARG42631 anti-CRMP1 antibody WB image
Western blot: SH-SY5Y cell lysate stained with ARG42631 anti-CRMP1 antibody.
