ARG55434
anti-CREB3L4 / AIBZIP antibody
anti-CREB3L4 / AIBZIP antibody for Western blot and Human
Gene Regulation antibody
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes CREB3L4 / AIBZIP |
|---|---|
| 反应物种 | Hu |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | CREB3L4 / AIBZIP |
| 抗原物种 | Human |
| 抗原 | KLH-conjugated synthetic peptide corresponding to aa. 338-366 (C-terminus) of Human CREB3L4. |
| 偶联标记 | Un-conjugated |
| 別名 | Transcript induced in spermiogenesis protein 40; cAMP-responsive element-binding protein 3-like protein 4; Androgen-induced basic leucine zipper protein; Cyclic AMP-responsive element-binding protein 3-like protein 4; cAMP-responsive element-binding protein 4; CREB4; CREB3; hJAL; Tisp40; ATCE1; JAL; Cyclic AMP-responsive element-binding protein 4; Attaching to CRE-like 1; CREB-4; AIbZIP; AIBZIP |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 阳性对照 | PC-3 |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein A and immunogen peptide. |
| 缓冲液 | PBS and 0.09% (W/V) Sodium azide |
| 抗菌剂 | 0.09% (W/V) Sodium azide |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q8TEY5 Human Cyclic AMP-responsive element-binding protein 3-like protein 4 |
|---|---|
| 基因名称 | CREB3L4 |
| 全名 | cAMP responsive element binding protein 3-like 4 |
| 背景介绍 | This gene encodes a CREB (cAMP responsive element binding) protein with a transmembrane domain which localizes it to the ER membrane. The encoded protein is a transcriptional activator which contains a dimerization domain, and this protein may function in a number of processing pathways including protein processing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011] |
| 生物功能 | Transcriptional activator that may play a role in the unfolded protein response. Binds to the UPR element (UPRE) but not to CRE element. Preferentially binds DNA with to the consensus sequence 5'-T[GT]ACGT[GA][GT]-3' and has transcriptional activation activity from UPRE. Binds to NF-kappa-B site and has transcriptional activation activity from NF-kappa-B-containing regulatory elements (By similarity). [UniProt] |
| 细胞定位 | Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein. Note=May also be located in Golgi apparatus |
| 研究领域 | Gene Regulation antibody |
| 预测分子量 | 43 kDa |
| 翻译后修饰 | N-glycosylated in the C-terminal region. Controlled by regulated intramembrane proteolysis (RIP). Following ER stress a fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage seems to be performed sequentially by site-1 and site-2 proteases (PS1 and PS2). PS1 cleavage may be suppressed by a determinant in the C-terminal region (By similarity). |
检测图片 (1) Click the Picture to Zoom In
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ARG55434 anti-CREB3L4 / AIBZIP antibody WB image
Western blot: 35 µg of PC-3 cell lysate stained with ARG55434 anti-CREB3L4 / AIBZIP antibody.
