ARG42553
anti-CREB3L3 / CREB-H antibody
anti-CREB3L3 / CREB-H antibody for Western blot and Human
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes CREB3L3 / CREB-H |
|---|---|
| 反应物种 | Hu |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | CREB3L3 / CREB-H |
| 抗原物种 | Human |
| 抗原 | KLH-conjugated synthetic peptide between aa. 244-274 of Human CREB3L3 / CREB-H. |
| 偶联标记 | Un-conjugated |
| 別名 | Cyclic AMP-responsive element-binding protein 3-like protein 3; Transcription factor CREB-H; cAMP-responsive element-binding protein 3-like protein 3; HYST1481; CREB-H; CREBH |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 阳性对照 | Human liver | ||||
| 实际分子量 | ~ 45 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein A and immunogen peptide. |
| 缓冲液 | PBS and 0.09% (W/V) Sodium azide. |
| 抗菌剂 | 0.09% (W/V) Sodium azide |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q68CJ9 Human Cyclic AMP-responsive element-binding protein 3-like protein 3 |
|---|---|
| 基因名称 | CREB3L3 |
| 全名 | cAMP responsive element binding protein 3-like 3 |
| 背景介绍 | This gene encodes a member of the basic-leucine zipper family and the AMP-dependent transcription factor family. The encoded protein is localized to the endoplasmic reticulum and acts as a transcription factor activated by cyclic AMP stimulation. The encoded protein binds the cyclic AMP response element (CRE) and the box-B element and has been linked to acute inflammatory response, hepatocellular carcinoma, triglyceride metabolism, and hepcidin expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012] |
| 生物功能 | Transcription factor that may act during endoplasmic reticulum stress by activating unfolded protein response target genes. Activated in response to cAMP stimulation. In vitro, binds to the cAMP response element (CRE) and box-B element. Activates transcription through box-B element. Activates transcription through CRE (By similarity). Seems to function synergistically with ATF6. In acute inflammatory response, may activate expression of acute phase response (APR) genes. May be involved in growth suppression. [UniProt] |
| 细胞定位 | Endoplasmic reticulum membrane; Single-pass type II membrane protein. Processed cyclic AMP-responsive element-binding protein 3-like protein 3: Nucleus. Note=Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus. [UniProt] |
| 预测分子量 | 49 kDa |
| 翻译后修饰 | Controlled by regulated intramembrane proteolysis (RIP). Following ER stress a fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage seems to be performed sequentially by site-1 and site-2 proteases (PS1 and PS2). N- and O-glycosylated. N-glycosylation is required for optimal proteolytic activation. O-glycosylated with core 1 or possibly core 8 glycans. [UniProt] |
检测图片 (1) Click the Picture to Zoom In
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ARG42553 anti-CREB3L3 / CREB-H antibody WB image
Western blot: 20 µg of Human liver lysate stained with ARG42553 anti-CREB3L3 / CREB-H antibody at 1:1000 - 1:2000 dilution.
