ARG44026
anti-CRBN antibody
anti-CRBN antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes CRBN |
|---|---|
| 反应物种 | Hu, Rat |
| 预测物种 | Ms |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | CRBN |
| 抗原物种 | Human |
| 抗原 | Human CRBN recombinantprotein |
| 偶联标记 | Un-conjugated |
| Protein Full name | CRBN |
| 別名 | CRBN; Cereblon; MRT2; Protein Cereblon; MRT2A; Mental Retardation, Non-Syndromic, Autosomal Recessive, 2A; Protein X 0001 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS containing 0.02% sodium azide |
| 抗菌剂 | 0.02% sodium azide |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | CRBN |
| 全名 | Cereblon |
| 背景介绍 | This gene encodes a protein related to the Lon protease protein family. In rodents and other mammals this gene product is found in the cytoplasm localized with a calcium channel membrane protein, and is thought to play a role in brain development. Mutations in this gene are associated with autosomal recessive nonsyndromic cognitive disability. Multiple transcript variants encoding different isoforms have been found for this gene. |
| 生物功能 | Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2 or ILF2. |
| 细胞定位 | Cytoplasm, Membrane, Nucleus |
| 预测分子量 | 51 kDa |
| 翻译后修饰 | Phosphoprotein, Ubl conjugation |
检测图片 (2) Click the Picture to Zoom In
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ARG44026 anti-CRBN antibody IHC-P image
Immunohistochemistry: Rat testis stained with ARG44026 anti-CRBN antibody at 5 μg/ml dilution.
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ARG44026 anti-CRBN antibody WB image
Western blot: Human testis stained with ARG44026 anti-CRBN antibody at 1 μg/ml dilution.
