ARG44909
anti-COREST / RCOR1 antibody
anti-COREST / RCOR1 antibody for IHC-Formalin-fixed paraffin-embedded sections,Immunoprecipitation,Western blot and Human
概述
| 产品描述 | Mouse Monoclonal antibody recognizes COREST / RCOR1 |
|---|---|
| 反应物种 | Hu |
| 应用 | IHC-P, IP, WB |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 同位型 | IgG1 |
| 靶点名称 | COREST / RCOR1 |
| 抗原物种 | Human |
| 抗原表位 | RKQKREREES EDELEEANGN NPIDIEVDQN KESKKEVPPT ETVPQVKKEK HSTQAKNRAK RKPPKGMFLS QEDVEAVSAN ATAATTVLRQ LDMELVSVKR QIQNIKQTNS ALKEKLDGGI EPYRLPEVIQ KCNARWTTEE QLLAVQAIRK YGRDFQAISD VIGNKSVVQV KNFFVNYRRR FNIDEVLQEW EAEHGKEETN GPSNQKPVKS PDNSIKMPEE |
| 偶联标记 | Un-conjugated |
| 別名 | RCOR1; REST Corepressor 1; KIAA0071; COREST; RCOR; REST Corepressor; Protein CoREST |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Protein A purification |
| 缓冲液 | PBS with 0.09% sodium azide |
| 抗菌剂 | 0.09% sodium azide |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | RCOR1 |
| 全名 | REST Corepressor 1 |
| 背景介绍 | This gene encodes a protein that is well-conserved, downregulated at birth, and with a specific role in determining neural cell differentiation. The encoded protein binds to the C-terminal domain of REST (repressor element-1 silencing transcription factor). [provided by RefSeq, Aug 2011] |
| 生物功能 | Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation. [Uniprot] |
| 细胞定位 | Nucleus. [Uniprot] |
| 预测分子量 | 53 kDa |
| 翻译后修饰 | Isopeptide bond, Phosphoprotein, Ubl conjugation. [Uniprot] |
检测图片 (3) Click the Picture to Zoom In
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ARG44909 anti-COREST / RCOR1 antibody IHC-P image
Immunohistochemistry: Human testis stained with ARG44909 anti-COREST / RCOR1 antibody at 7.5 µg/mL dilution.
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ARG44909 anti-COREST / RCOR1 antibody WB image
Western blot: Jurkat stained with ARG44909 anti-COREST / RCOR1 antibody at 1 µg/mL dilution.
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ARG44909 anti-COREST / RCOR1 antibody IP image
Immunoprecipitation: Jurkat lysate immunoprecipitated with 2.5 µg of ARG44909 anti-COREST / RCOR1 antibody.
