ARG63318
anti-COPS2 / TRIP15 antibody
anti-COPS2 / TRIP15 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse
Gene Regulation antibody; Signaling Transduction antibody
概述
| 产品描述 | Goat Polyclonal antibody recognizes COPS2 / TRIP15 |
|---|---|
| 反应物种 | Hu, Ms |
| 预测物种 | Cow, Rat, Dog |
| 应用 | IHC-P, WB |
| 宿主 | Goat |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | COPS2 / TRIP15 |
| 抗原物种 | Human |
| 抗原 | C-LNSLNQAVVSKLA |
| 偶联标记 | Un-conjugated |
| 別名 | Alien homolog; Thyroid receptor-interacting protein 15; COP9 signalosome complex subunit 2; TR-interacting protein 15; SGN2; Signalosome subunit 2; JAB1-containing signalosome subunit 2; ALIEN; CSN2; TRIP-15; TRIP15 |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|---|---|
| 应用说明 | WB: Recommend incubate at RT for 1h. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purified from goat serum by antigen affinity chromatography. |
| 缓冲液 | Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 0.5% BSA |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # P61201 Human COP9 signalosome complex subunit 2 Swiss-port # P61202 Mouse COP9 signalosome complex subunit 2 |
|---|---|
| 基因名称 | COPS2 |
| 全名 | COP9 signalosome subunit 2 |
| 生物功能 | Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1. [UniProt] |
| 研究领域 | Gene Regulation antibody; Signaling Transduction antibody |
| 预测分子量 | 52 kDa |
| 翻译后修饰 | Phosphorylated by CK2 and PKD kinases. |
检测图片 (2) Click the Picture to Zoom In
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ARG63318 anti-COPS2 / TRIP15 antibody WB image
Western Blot: NIH-3T3 lysates (RIPA buffer, 30µg total protein per lane) stained with ARG63318 anti-COPS2 / TRIP15 antibody at 0.03 µg/ml dilution.
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ARG63318 anti-COPS2 / TRIP15 antibody IHC-P image
Immunohistochemistry: In paraffin embedded Human Thyroid Gland stained with ARG63318 anti-COPS2 / TRIP15 antibody shows nclear and cytoplasm staining in activated epithelial cells. Recommended concentration, 3-5µg/ml.
