ARG64754
anti-COL4A3BP antibody
anti-COL4A3BP antibody for Western blot and Human
Cancer antibody; Cell Biology and Cellular Response antibody; Immune System antibody; Metabolism antibody; Signaling Transduction antibody
概述
| 产品描述 | Goat Polyclonal antibody recognizes COL4A3BP |
|---|---|
| 反应物种 | Hu |
| 预测物种 | Cow, Dog |
| 应用 | WB |
| 特异性 | This antibody is expected to recognize both reported isoforms (NP_005704.1; NP_112729.1). |
| 宿主 | Goat |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | COL4A3BP |
| 抗原物种 | Human |
| 抗原 | C-KREDSWQKRLDKETEK |
| 偶联标记 | Un-conjugated |
| 別名 | START domain-containing protein 11; STARD11; Goodpasture antigen-binding protein; StARD11; Ceramide transfer protein; CERTL; StAR-related lipid transfer protein 11; CERT; GPBP; MRD34; Collagen type IV alpha-3-binding protein; hCERT |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|
| 应用说明 | WB: Recommend incubate at RT for 1h. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purified from goat serum by antigen affinity chromatography. |
| 缓冲液 | Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 0.5% BSA |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q9Y5P4 Human Collagen type IV alpha-3-binding protein |
|---|---|
| 背景介绍 | This gene encodes a kinase that specifically phosphorylates the N-terminal region of the non-collagenous domain of the alpha 3 chain of type IV collagen, known as the Goodpasture antigen. Goodpasture disease is the result of an autoimmune response directed at this antigen. One isoform of this protein is also involved in ceramide intracellular transport. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| 研究领域 | Cancer antibody; Cell Biology and Cellular Response antibody; Immune System antibody; Metabolism antibody; Signaling Transduction antibody |
| 预测分子量 | 71 kDa |
| 翻译后修饰 | Phosphorylation on Ser-132 decreases the affinity toward phosphatidylinositol 4-phosphate at Golgi membranes and reduces ceramide transfer activity. Inactivated by hyperphosphorylation of serine residues by CSNK1G2/CK1 that triggers dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. |
检测图片 (1) Click the Picture to Zoom In
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ARG64754 anti-COL4A3BP antibody WB image
Western Blot: Human Heart lysate (35 µg protein in RIPA buffer) stained with ARG64754 anti-COL4A3BP (aa396-411) antibody at 1 µg/ml dilution.
