ARG44316
anti-COL25A1 antibody
anti-COL25A1 antibody for Western blot and Human,Mouse
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes COL25A1 |
|---|---|
| 反应物种 | Hu, Ms |
| 应用 | WB |
| 特异性 | This antibody is design for isoform 2 |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | COL25A1 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide |
| 偶联标记 | Un-conjugated |
| 別名 | COL25A1; Collagen Type XXV Alpha 1 Chain; Alzheimer Disease Amyloid-Associated Protein; Collagen Alpha-1(XXV) Chain; CLAC-P; AMY; Collagen-Like Alzheimer Amyloid Plaque Component; Collagenous Alzheimer Amyloid Plaque Component; Collagen, Type XXV, Alpha 1; CFEOM5; CLACP; CLAC |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Antigen Affinity Purified |
| 缓冲液 | PBS with 0.02% Sodium azide |
| 抗菌剂 | 0.02% Sodium azide |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | COL25A1 |
| 全名 | Collagen Type XXV Alpha 1 Chain |
| 背景介绍 | This gene encodes a brain-specific membrane associated collagen. A product of proteolytic processing of the encoded protein, CLAC (collagenous Alzheimer amyloid plaque component), binds to amyloid beta-peptides found in Alzheimer amyloid plaques but CLAC inhibits rather than facilitates amyloid fibril elongation (PMID: 16300410). A study of over-expression of this collagen in mice, however, found changes in pathology and behavior suggesting that the encoded protein may promote amyloid plaque formation (PMID: 19548013). Multiple transcript variants encoding different isoforms have been found for this gene. |
| 生物功能 | Inhibits fibrillization of amyloid-beta peptide during the elongation phase. Has also been shown to assemble amyloid fibrils into protease-resistant aggregates. Binds heparin. |
| 细胞定位 | Amyloid, Membrane |
| 预测分子量 | 64 kDa |
| 翻译后修饰 | Glycoprotein, Hydroxylation, Pyrrolidone carboxylic acid |
