ARG41673
anti-CNTNAP1 / Caspr 1 antibody
anti-CNTNAP1 / Caspr 1 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes CNTNAP1 / Caspr 1 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | CNTNAP1 / Caspr 1 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide of Human CNTNAP1 / Caspr 1. |
| 偶联标记 | Un-conjugated |
| 別名 | Neurexin-4; CNTNAP; Contactin-associated protein 1; NRXN4; Caspr; Caspr1; CASPR; P190; p190; Neurexin IV |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | U-87 MG |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.4), 150 mM NaCl, 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | CNTNAP1 |
| 全名 | contactin associated protein 1 |
| 背景介绍 | The gene product was initially identified as a 190-kD protein associated with the contactin-PTPRZ1 complex. The 1,384-amino acid protein, also designated p190 or CASPR for 'contactin-associated protein,' includes an extracellular domain with several putative protein-protein interaction domains, a putative transmembrane domain, and a 74-amino acid cytoplasmic domain. Northern blot analysis showed that the gene is transcribed predominantly in brain as a transcript of 6.2 kb, with weak expression in several other tissues tested. The architecture of its extracellular domain is similar to that of neurexins, and this protein may be the signaling subunit of contactin, enabling recruitment and activation of intracellular signaling pathways in neurons. [provided by RefSeq, Jan 2009] |
| 生物功能 | Seems to play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Seems to demarcate the paranodal region of the axo-glial junction. In association with contactin may have a role in the signaling between axons and myelinating glial cells. [UniProt] |
| 细胞定位 | Membrane; Single-pass type I membrane protein. Cell junction, paranodal septate junction. [UniProt] |
| 预测分子量 | 156 kDa |
检测图片 (1) Click the Picture to Zoom In
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ARG41673 anti-CNTNAP1 / Caspr 1 antibody WB image
Western blot: U-87 MG cell lysate stained with ARG41673 anti-CNTNAP1 / Caspr 1 antibody.
