ARG44644
anti-CMTM6 antibody
anti-CMTM6 antibody for IHC-Formalin-fixed paraffin-embedded sections,Immunoprecipitation,Western blot and Human
概述
| 产品描述 | Mouse Monoclonal antibody recognizes CMTM6 |
|---|---|
| 反应物种 | Hu |
| 应用 | IHC-P, IP, WB |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 同位型 | IgG1 |
| 靶点名称 | CMTM6 |
| 抗原物种 | Human |
| 偶联标记 | Un-conjugated |
| 別名 | CMTM6; CKLF Like MARVEL Transmembrane Domain Containing 6; CKLFSF6; CKLF-Like MARVEL Transmembrane Domain-Containing Protein 6; Chemokine-Like Factor Superfamily Member 6; Chemokine-Like Factor Super Family 6; Chemokine-Like Factor Superfamily 6; FLJ20396; CKLF-Like MARVEL Transmembrane Domain Containing 6; PRO2219 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Protein A purification |
| 缓冲液 | PBS with 0.09% sodium azide |
| 抗菌剂 | 0.09% sodium azide |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q9NX76 Human CKLF-like MARVEL transmembrane domain-containing protein 6 |
|---|---|
| 基因名称 | CMTM6 |
| 全名 | CKLF Like MARVEL Transmembrane Domain Containing 6 |
| 背景介绍 | This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and transmembrane 4 superfamilies. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 3. This gene is widely expressed in many tissues, but the exact function of the encoded protein is unknown. [provided by RefSeq, Jul 2008] |
| 生物功能 | Master regulator of recycling and plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. Associates with both constitutive and IFNG-induced PD-L1/CD274 at recycling endosomes, where it protects PD-L1/CD274 from being targeted for lysosomal degradation, likely by preventing its STUB1-mediated ubiquitination. May stabilize PD-L1/CD274 expression on antigen presenting cells and potentiates inhibitory signaling by PDCD1/CD279, its receptor on T-cells, ultimately triggering T-cell anergy. [UniProt] |
| 细胞定位 | Cell membrane, Endosome, Membrane. [UniProt] |
| 预测分子量 | 20 kDa |
| 翻译后修饰 | Acetylation, Phosphoprotein. [UniProt] |
检测图片 (3) Click the Picture to Zoom In
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ARG44644 anti-CMTM6 antibody IHC-P image
Immunohistochemistry: Humam Endometrium stained with ARG44644 anti-CMTM6 antibody at 5 µg/mL dilution.
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ARG44644 anti-CMTM6 antibody WB image
Western blot: Jurkat stained with ARG44644 anti-CMTM6 antibody at 1 µg/mL dilution.
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ARG44644 anti-CMTM6 antibody IP image
Immunoprecipitation: Jurkat lysate immunoprecipitated with 2.5 µg of ARG44644 anti-CMTM6 antibody.
