ARG42357
anti-CLEC9A antibody [8F9] (PE)
anti-CLEC9A antibody [8F9] (PE) for Flow cytometry and Human
概述
| 产品描述 | PE-conjugated Mouse Monoclonal antibody [8F9] recognizes CLEC9A |
|---|---|
| 反应物种 | Hu |
| 应用 | FACS |
| 特异性 | The mouse monoclonal antibody 8F9 recognizes an extracellular epitope of CD370 / CLEC9A (DNGR1), a type II transmembrane protein functioning as an endocytic receptor on BDCA31+ dendritic cells and on a subset of CD14+ CD16- monocytes. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | 8F9 |
| 同位型 | IgG2a |
| 靶点名称 | CLEC9A |
| 抗原物种 | Human |
| 抗原 | RBL-2H3 cells expressing Human CLEC9A fused to an HA epitope. |
| 偶联标记 | PE |
| 別名 | UNQ9341; C-type lectin domain family 9 member A; CD370; DNGR-1; DNGR1 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purified |
| 缓冲液 | PBS and 15 mM Sodium azide. |
| 抗菌剂 | 15 mM Sodium azide |
| 存放说明 | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q6UXN8 Human C-type lectin domain family 9 member A |
|---|---|
| 基因名称 | CLEC9A |
| 全名 | C-type lectin domain family 9, member A |
| 背景介绍 | CLEC9A is a group V C-type lectin-like receptor (CTLR) that functions as an activation receptor and is expressed on myeloid lineage cells (Huysamen et al., 2008 [PubMed 18408006]).[supplied by OMIM, Aug 2008] |
| 生物功能 | Functions as an endocytic receptor on a small subset of myeloid cells specialized for the uptake and processing of material from dead cells. Recognizes filamentous form of actin in association with particular actin-binding domains of cytoskeletal proteins, including spectrin, exposed when cell membranes are damaged, and mediate the cross-presentation of dead-cell associated antigens in a Syk-dependent manner. [UniProt] |
| 细胞定位 | Membrane; Single-pass type II membrane protein. [UniProt] |
| 预测分子量 | 27 kDa |
| 翻译后修饰 | N-glycosylated. [UniProt] |
检测图片 (3) Click the Picture to Zoom In
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ARG42357 anti-CLEC9A antibody [8F9] (PE) FACS image
Flow Cytometry: Human peripheral whole blood stained with ARG42357 anti-CLEC9A antibody [8F9] (PE) at 10 µl / 100 µl of peripheral whole blood.
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ARG42357 anti-CLEC9A antibody [8F9] (PE) FACS image
Flow Cytometry: Human peripheral blood mononuclear cells stained with ARG42357 anti-CLEC9A antibody [8F9] (PE) at 10 µl / 100 µl of peripheral whole blood and ARG53938 anti-HLA DR antibody [MEM-12] (APC) at 10 µl / 100 µl of peripheral whole blood.
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ARG42357 anti-CLEC9A antibody [8F9] (PE) FACS image
Flow Cytometry: Separation of Human CD370 positive HLA-DR positive cells (red-filled) from CD370 negative HLA-DR negative cells (black-dashed). Human peripheral whole blood stained with ARG42357 anti-CLEC9A antibody [8F9] (PE) at 10 µl / 100 µl of peripheral whole blood.
