ARG58387
anti-CLCN5 antibody
anti-CLCN5 antibody for Western blot and Human,Mouse
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes CLCN5 |
|---|---|
| 反应物种 | Hu, Ms |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | CLCN5 |
| 抗原物种 | Human |
| 抗原 | Recombinant fusion protein corresponding to aa. 637-816 of Human CLCN5 (NP_001121370.1). |
| 偶联标记 | Un-conjugated |
| 別名 | XRN; CLC5; XLRH; CLCK2; ClC-5; DENTS; NPHL1; NPHL2; hCIC-K2; H(+)/Cl(-) exchange transporter 5; Chloride channel protein 5; ClC-5; Chloride transporter ClC-5 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 阳性对照 | SW480 | ||||
| 实际分子量 | 100 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | CLCN5 |
| 全名 | chloride channel, voltage-sensitive 5 |
| 背景介绍 | This gene encodes a member of the ClC family of chloride ion channels and ion transporters. The encoded protein is primarily localized to endosomal membranes and may function to facilitate albumin uptake by the renal proximal tubule. Mutations in this gene have been found in Dent disease and renal tubular disorders complicated by nephrolithiasis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2013] |
| 生物功能 | Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons. Important for normal acidification of the endosome lumen. May play an important role in renal tubular function. [UniProt] |
| 细胞定位 | Golgi apparatus membrane, Multi-pass membrane protein, Endosome membrane, Cell membrane. [UniProt] |
| 预测分子量 | 83 kDa |
| 翻译后修饰 | Ubiquitinated by NEDD4L in the presence of albumin; which promotes endocytosis and proteasomal degradation. [UniProt] |
检测图片 (1) Click the Picture to Zoom In
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ARG58387 anti-CLCN5 antibody WB image
Western blot: 25 µg of SW480 cell lysate stained with ARG58387 anti-CLCN5 antibody at 1:1000 dilution.
