ARG57513
anti-CIDE C antibody
anti-CIDE C antibody for Western blot and Human,Mouse
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes CIDE C |
|---|---|
| 反应物种 | Hu, Ms |
| 预测物种 | Rat |
| 应用 | WB |
| 特异性 | This antibody recognizes Human CIDE C. Sequence homology to the Mouse CIDE C homolog, FSP27, is 93%. |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | CIDE C |
| 抗原物种 | Human |
| 抗原 | KLH-conjugated synthetic peptide around aa. 10-25 of Human CIDE C. (LLYPKSLSRHVSVRTS) |
| 偶联标记 | Un-conjugated |
| 別名 | CIDE3; Fat-specific protein FSP27 homolog; Cell death-inducing DFFA-like effector protein C; Cell death activator CIDE-3; FSP27; CIDE-3; FPLD5 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 阳性对照 | HepG2 cell lysate. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purified by immunoaffinity chromatography. |
| 缓冲液 | PBS (pH 7.4) |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | CIDEC |
| 全名 | cell death-inducing DFFA-like effector c |
| 背景介绍 | This gene encodes a member of the cell death-inducing DNA fragmentation factor-like effector family. Members of this family play important roles in apoptosis. The encoded protein promotes lipid droplet formation in adipocytes and may mediate adipocyte apoptosis. This gene is regulated by insulin and its expression is positively correlated with insulin sensitivity. Mutations in this gene may contribute to insulin resistant diabetes. A pseudogene of this gene is located on the short arm of chromosome 3. Alternatively spliced transcript variants that encode different isoforms have been observed for this gene. [provided by RefSeq, Dec 2010] |
| 生物功能 | Binds to lipid droplets and regulates their enlargement, thereby restricting lipolysis and favoring storage. At focal contact sites between lipid droplets, promotes directional net neutral lipid transfer from the smaller to larger lipid droplets. The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair. Its role in neutral lipid transfer and lipid droplet enlargement is activated by the interaction with PLIN1. May act as a CEBPB coactivator in the white adipose tissue to control the expression of a subset of CEBPB downstream target genes, including SOCS1, SOCS3, TGFB1, TGFBR1, ID2 and XDH. When overexpressed in preadipocytes, induces apoptosis or increases cell susceptibility to apoptosis induced by serum deprivation or TGFB treatment. As mature adipocytes, that express high CIDEC levels, are quite resistant to apoptotic stimuli, the physiological significance of its role in apoptosis is unclear. May play a role in the modulation of the response to osmotic stress by preventing NFAT5 to translocate into the nucleus and activate its target genes expression. [UniProt] |
| 预测分子量 | 27 kDa |
| 翻译后修饰 | Ubiquitinated and targeted to proteasomal degradation, resulting in a short half-life. Protein stability depends on triaclyglycerol synthesis, fatty acid availability and lipid droplet formation (By similarity). [UniProt] |
检测图片 (1) Click the Picture to Zoom In
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ARG57513 anti-CIDE C antibody WB image
Western blot: 30 µg of HepG2 cell lysate stained with ARG57513 anti-CIDE C antibody at 1:1000 dilution.
