ARG41754
anti-CHRM2 / M2 mAChR antibody
anti-CHRM2 / M2 mAChR antibody for Western blot and Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes CHRM2 / M2 mAChR |
|---|---|
| 反应物种 | Ms, Rat |
| 预测物种 | Hu |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | CHRM2 / M2 mAChR |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide corresponding to aa. 352-376 of Human CHRM2. (QNGDEKQNIVARKIVKMTKQPAKKK) |
| 偶联标记 | Un-conjugated |
| 別名 | Muscarinic acetylcholine receptor M2; HM2 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 实际分子量 | ~ 54 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | 0.2% Na2HPO4, 0.9% NaCl, 0.05% Sodium azide and 5% BSA. |
| 抗菌剂 | 0.05% Sodium azide |
| 稳定剂 | 5% BSA |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q9ERZ4 Mouse Muscarinic acetylcholine receptor M2 |
|---|---|
| 基因名称 | CHRM2 |
| 全名 | cholinergic receptor, muscarinic 2 |
| 背景介绍 | The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine to these receptors and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 2 is involved in mediation of bradycardia and a decrease in cardiac contractility. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008] |
| 生物功能 | The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol. [UniProt] |
| 细胞定位 | Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Phosphorylation in response to agonist binding promotes receptor internalization. [UniProt] |
| 预测分子量 | 52 kDa |
| 翻译后修饰 | Phosphorylated in response to agonist treatment. [UniProt] |
检测图片 (1) Click the Picture to Zoom In
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ARG41754 anti-CHRM2 / M2 mAChR antibody WB image
Western blot: Rat brain and Mouse brain lysates stained with ARG41754 anti-CHRM2 / M2 mAChR antibody at 0.5 µg/ml dilution.
