ARG45801
anti-CHP2 antibody
anti-CHP2 antibody for Flow cytometry,ICC/IF,Western blot and Human
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes CHP2 |
|---|---|
| 反应物种 | Hu |
| 应用 | FACS, ICC/IF, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | CHP2 |
| 抗原物种 | Human |
| 抗原 | Recombinant protein containing to human CHP2. |
| 偶联标记 | Un-conjugated |
| 別名 | CHP2; Calcineurin Like EF-Hand Protein 2; Hepatocellular Carcinoma-Associated Antigen 520; Calcineurin B Homologous Protein 2; Hepatocellular Carcinoma Antigen Gene 520; HCA520 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| 实际分子量 | 22 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified |
| 缓冲液 | 0.2% Na2HPO4, 0.9% NaCl and 4% Trehalose. |
| 稳定剂 | 4% Trehalose |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # O43745 Human Calcineurin B homologous protein 2 |
|---|---|
| 基因名称 | CHP2 |
| 全名 | Calcineurin Like EF-Hand Protein 2 |
| 背景介绍 | This gene product is a small calcium-binding protein that regulates cell pH by controlling plasma membrane-type Na+/H+ exchange activity. This protein shares sequence similarity with calcineurin B and can bind to and stimulate the protein phosphatase activity of calcineurin A (CnA) and functions in the calcineurin/NFAT (nuclear factor of activated T cells) signaling pathway. Another member of the CHP subfamily, Calcineurin B homologous protein 1, is located on Chromosome 15 and is an inhibitor of calcineurin activity and has a genetic phenotype associated with Parkinson's Disease (OMIM:606988). This gene was initially identified as a tumor-associated antigen and was previously referred to as Hepatocellular carcinoma-associated antigen 520. [provided by RefSeq, Jul 2013] |
| 生物功能 | Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation-induced death. Also plays a role in the regulation of cell proliferation and tumor growth by increasing the phosphatase activity of PPP3CA in a calcium-dependent manner. Activator of the calcineurin/NFAT signaling pathway. Involved in the cytoplasmic translocation of the transcription factor NFATC3 to the nucleus. [UniProt] |
| 细胞定位 | Cell membrane; Cytoplasm; Membrane; Nucleus. [UniProt] |
| 预测分子量 | 22 kDa |
| 翻译后修饰 | Lipoprotein; Myristate; Phosphoprotein. [UniProt] |
检测图片 (3) Click the Picture to Zoom In
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ARG45801 anti-CHP2 antibody ICC/IF image
Immunofluorescence: Hela stained with ARG45801 anti-CHP2 antibody at 5 μg/ml dilution.
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ARG45801 anti-CHP2 antibody WB image
Western blot: Hela stained with ARG45801 anti-CHP2 antibody at 0.5 μg/ml dilution.
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ARG45801 anti-CHP2 antibody FACS image
Flow Cytometry: HepG2 stained with ARG45801 anti-CHP2 antibody at 1 µg/10^6 cells dilution.
