ARG55058
anti-CHML antibody (C-term)
anti-CHML antibody (C-term) for Western blot and Human,Mouse
Neuroscience antibody; Signaling Transduction antibody
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes CHML |
|---|---|
| 反应物种 | Hu, Ms |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | CHML |
| 抗原物种 | Human |
| 抗原 | Recombinant protein of Human CHML (C-terminus) (Swiss: Q9UQN3) |
| 偶联标记 | Un-conjugated |
| 別名 | VPS2B; Charged multivesicular body protein 2b; Vacuolar protein sorting-associated protein 2-2; hVps2-2; DMT1; ALS17; CHMP2b; VPS2-2; CHMP2.5; Vps2-2; Chromatin-modifying protein 2b |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 阳性对照 | BT474 and Mouse kidney |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q8BJF9 Mouse Charged multivesicular body protein 2b Swiss-port # Q9UQN3 Human Charged multivesicular body protein 2b |
|---|---|
| 基因名称 | CHMP2B |
| 全名 | charged multivesicular body protein 2B |
| 背景介绍 | This gene encodes a component of the heteromeric ESCRT-III complex (Endosomal Sorting Complex Required for Transport III) that functions in the recycling or degradation of cell surface receptors. ESCRT-III functions in the concentration and invagination of ubiquitinated endosomal cargos into intralumenal vesicles. The protein encoded by this gene is found as a monomer in the cytosol or as an oligomer in ESCRT-III complexes on endosomal membranes. It is expressed in neurons of all major regions of the brain. Mutations in this gene result in one form of familial frontotemporal lobar degeneration. [provided by RefSeq, Jul 2008] |
| 生物功能 | Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. [UniProt] |
| 研究领域 | Neuroscience antibody; Signaling Transduction antibody |
| 预测分子量 | 24 kDa |
检测图片 (2) Click the Picture to Zoom In
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ARG55058 anti-CHML antibody (C-term) WB image
Western blot: BT474 cell lysate stained with ARG55058 anti-CHML antibody (C-term).
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ARG55058 anti-CHML antibody (C-term) WB image
Western blot: Mouse kidney lysate stained with ARG55058 anti-CHML antibody (C-term).
