ARG59940
anti-CHIA / AMCase antibody
anti-CHIA / AMCase antibody for Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes CHIA / AMCase |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | CHIA / AMCase |
| 抗原物种 | Human |
| 抗原 | Recombinant fusion protein corresponding to aa. 1-368 of Human CHIA (NP_001244932.1). |
| 偶联标记 | Un-conjugated |
| 別名 | EC 3.2.1.14; Lung-specific protein TSA1902; CHIT2; TSA1902; AMCase; AMCASE; Acidic mammalian chitinase |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 阳性对照 | Rat stomach and Mouse stomach | ||||
| 实际分子量 | 50-55 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | CHIA |
| 全名 | chitinase, acidic |
| 背景介绍 | The protein encoded by this gene degrades chitin, which is found in the cell wall of most fungi as well as in arthropods and some nematodes. The encoded protein can also stimulate interleukin 13 expression, and variations in this gene can lead to asthma susceptibility. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Apr 2012] |
| 生物功能 | Degrades chitin and chitotriose. May participate in the defense against nematodes, fungi and other pathogens. Plays a role in T-helper cell type 2 (Th2) immune response. Contributes to the response to IL-13 and inflammation in response to IL-13. Stimulates chemokine production by pulmonary epithelial cells. Protects lung epithelial cells against apoptosis and promotes phosphorylation of AKT1. Its function in the inflammatory response and in protecting cells against apoptosis is inhibited by allosamidin, suggesting that the function of this protein depends on carbohydrate binding. [UniProt] |
| 细胞定位 | Isoform 1: Secreted. Note=Secretion depends on EGFR activity. Isoform 2: Cytoplasm. Isoform 3: Cytoplasm. [UniProt] |
| 预测分子量 | 52 kDa |
检测图片 (1) Click the Picture to Zoom In
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ARG59940 anti-CHIA / AMCase antibody WB image
Western blot: 25 µg of Rat stomach and Mouse stomach lysates stained with ARG59940 anti-CHIA / AMCase antibody at 1:1000 dilution.
