ARG62582
anti-CDKN1C / p57 Kip2 antibody [KP39]
anti-CDKN1C / p57 Kip2 antibody [KP39] for IHC-Formalin-fixed paraffin-embedded sections,Immunoprecipitation and Human,Mouse,Rat
Cancer antibody; Cell Biology and Cellular Response antibody; Gene Regulation antibody
概述
| 产品描述 | Mouse Monoclonal antibody [KP39] recognizes CDKN1C / p57 Kip2 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | IHC-P, IP |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | KP39 |
| 同位型 | IgG2b |
| 靶点名称 | CDKN1C / p57 Kip2 |
| 抗原物种 | Human |
| 抗原 | Recombinant full length protein (Human). |
| 偶联标记 | Un-conjugated |
| 別名 | Cyclin-dependent kinase inhibitor p57; BWS; WBS; BWCR; KIP2; Cyclin-dependent kinase inhibitor 1C; p57; p57Kip2 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | IgG purified |
| 缓冲液 | 10mM PBS (pH 7.4), 0.2% BSA and 0.09% Sodium azide |
| 抗菌剂 | 0.09% Sodium azide |
| 稳定剂 | 0.2% BSA |
| 浓度 | 0.2 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # P49918 Human Cyclin-dependent kinase inhibitor 1C Swiss-port # P49919 Mouse Cyclin-dependent kinase inhibitor 1C |
|---|---|
| 基因名称 | CDKN1C |
| 全名 | cyclin-dependent kinase inhibitor 1C (p57, Kip2) |
| 背景介绍 | This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2010] |
| 生物功能 | Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life. [UniProt] |
| 细胞定位 | Nucleus |
| 研究领域 | Cancer antibody; Cell Biology and Cellular Response antibody; Gene Regulation antibody |
| 预测分子量 | 32 kDa |
克隆号文献
BMP10 is essential for maintaining cardiac growth during murine cardiogenesis.
IHC / Mouse
Expression and activity of the CDK inhibitor p57Kip2 in chondrocytes undergoing hypertrophic differentiation.
WB / Rat
