ARG41620
anti-CDKN1C / p57 Kip2 antibody
anti-CDKN1C / p57 Kip2 antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Immunoprecipitation,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes CDKN1C / p57 Kip2 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | ICC/IF, IHC-P, IP, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | CDKN1C / p57 Kip2 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide of Human CDKN1C / p57 Kip2. |
| 偶联标记 | Un-conjugated |
| 別名 | Cyclin-dependent kinase inhibitor p57; BWS; WBS; BWCR; KIP2; Cyclin-dependent kinase inhibitor 1C; p57; p57Kip2 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||||
| 阳性对照 | HeLa | ||||||||||
| 实际分子量 | ~ 50 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.4), 150 mM NaCl, 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # P49918 Human Cyclin-dependent kinase inhibitor 1C Swiss-port # P49919 Mouse Cyclin-dependent kinase inhibitor 1C |
|---|---|
| 基因名称 | CDKN1C |
| 全名 | cyclin-dependent kinase inhibitor 1C (p57, Kip2) |
| 背景介绍 | This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2010] |
| 生物功能 | Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life. [UniProt] |
| 细胞定位 | Nucleus. [UniProt] |
| 预测分子量 | 32 kDa |
检测图片 (3) Click the Picture to Zoom In
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ARG41620 anti-CDKN1C / p57 Kip2 antibody ICC/IF image
Immunofluorescence: HeLa cells treated with dexamethasone. Cells were stained with ARG41620 anti-CDKN1C / p57 Kip2 antibody.
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ARG41620 anti-CDKN1C / p57 Kip2 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Rat kidney tissue stained with ARG41620 anti-CDKN1C / p57 Kip2 antibody.
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ARG41620 anti-CDKN1C / p57 Kip2 antibody WB image
Western blot: HeLa cell lysate stained with ARG41620 anti-CDKN1C / p57 Kip2 antibody.
