ARG45747
anti-CDK5RAP2 antibody
anti-CDK5RAP2 antibody for ICC/IF,Western blot and Human
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes CDK5RAP2 |
|---|---|
| 反应物种 | Hu |
| 应用 | ICC/IF, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | CDK5RAP2 |
| 抗原物种 | Human |
| 抗原 | Recombinant protein containing to human CDK5RAP2. |
| 偶联标记 | Un-conjugated |
| 別名 | CDK5RAP2; CDK5 Regulatory Subunit Associated Protein 2; CEP215; C48; CDK5 Regulatory Subunit-Associated Protein 2; CDK5 Activator-Binding Protein C48; Centrosomin; FLJ10867; MCPH3; Microcephaly, Primary Autosomal Recessive 3; Centrosome-Associated Protein 215; Centrosomal Protein 215 KDa; KIAA1633 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 实际分子量 | 250 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified |
| 缓冲液 | 0.2% Na2HPO4, 0.9% NaCl and 4% Trehalose. |
| 稳定剂 | 4% Trehalose |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q96SN8 Human CDK5 regulatory subunit-associated protein 2 |
|---|---|
| 基因名称 | CDK5RAP2 |
| 全名 | CDK5 Regulatory Subunit Associated Protein 2 |
| 背景介绍 | This gene encodes a regulator of CDK5 (cyclin-dependent kinase 5) activity. The protein encoded by this gene is localized to the centrosome and Golgi complex, interacts with CDK5R1 and pericentrin (PCNT), plays a role in centriole engagement and microtubule nucleation, and has been linked to primary microcephaly and Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013] |
| 生物功能 | Potential regulator of CDK5 activity via its interaction with CDK5R1. Negative regulator of centriole disengagement (licensing) which maintains centriole engagement and cohesion. Involved in regulation of mitotic spindle orientation (By similarity). Plays a role in the spindle checkpoint activation by acting as a transcriptional regulator of both BUBR1 and MAD2 promoter. Together with EB1/MAPRE1, may promote microtubule polymerization, bundle formation, growth and dynamics at the plus ends. Regulates centrosomal maturation by recruitment of the gamma-tubulin ring complex (gamma-TuRC) onto centrosomes. [UniProt] |
| 细胞定位 | Cytoplasm; Cytoskeleton; Golgi apparatus; Microtubule. [UniProt] |
| 预测分子量 | 215 kDa |
| 翻译后修饰 | Phosphoprotein. [UniProt] |
检测图片 (2) Click the Picture to Zoom In
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ARG45747 anti-CDK5RAP2 antibody ICC/IF image
Immunofluorescence: Hela stained with ARG45747 anti-CDK5RAP2 antibody at 5 μg/ml dilution.
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ARG45747 anti-CDK5RAP2 antibody WB image
Western blot: HepG2 stained with ARG45747 anti-CDK5RAP2 antibody at 0.5 μg/ml dilution.
