ARG41804
anti-CDCA5 antibody
anti-CDCA5 antibody for Flow cytometry,ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes CDCA5 |
|---|---|
| 反应物种 | Hu |
| 应用 | FACS, ICC/IF, IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | CDCA5 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide of Human CDCA5. |
| 偶联标记 | Un-conjugated |
| 別名 | p35; SORORIN; Cell division cycle-associated protein 5; Sororin |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||||
| 阳性对照 | Jurkat | ||||||||||
| 实际分子量 | ~ 34 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.4), 150 mM NaCl, 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | CDCA5 |
| 全名 | cell division cycle associated 5 |
| 生物功能 | Regulator of sister chromatid cohesion in mitosis stabilizing cohesin complex association with chromatin. May antagonize the action of WAPAL which stimulates cohesin dissociation from chromatin. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Required for efficient DNA double-stranded break repair. [UniProt] |
| 细胞定位 | Nucleus. Chromosome. Cytoplasm. Note=Associates with nuclear chromatin from S phase until metaphase and is released in the cytoplasm upon nuclear envelope breakdown. [UniProt] |
| 预测分子量 | 28 kDa |
| 翻译后修饰 | Phosphorylated. Phosphorylation, as cells enter mitosis, disrupts the interaction with PDS5A and relieves the inhibition of WAPL by CDCA5. Ubiquitinated by the APC/C complex in G1, leading to its degradation. [UniProt] |
检测图片 (3) Click the Picture to Zoom In
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ARG41804 anti-CDCA5 antibody ICC/IF image
Immunofluorescence: HeLa cells stained with ARG41804 anti-CDCA5 antibody (red).
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ARG41804 anti-CDCA5 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human colon tissue stained with ARG41804 anti-CDCA5 antibody.
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ARG41804 anti-CDCA5 antibody WB image
Western blot: Jurkat cell lysate stained with ARG41804 anti-CDCA5 antibody.
