ARG55057
anti-CDC5L antibody
anti-CDC5L antibody for Western blot and Human,Mouse
Gene Regulation antibody
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes CDC5L |
|---|---|
| 反应物种 | Hu, Ms |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | CDC5L |
| 抗原物种 | Human |
| 抗原 | Recombinant protein of Human CDC5L (Swiss: Q99459) |
| 偶联标记 | Un-conjugated |
| 別名 | Cell division cycle 5-like protein; dJ319D22.1; PCDC5RP; Pombe cdc5-related protein; CEF1; CDC5-LIKE; Cdc5-like protein; CDC5 |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 阳性对照 | Mouse testis and SW480 |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q6A068 Mouse Cell division cycle 5-like protein Swiss-port # Q99459 Human Cell division cycle 5-like protein |
|---|---|
| 基因名称 | CDC5L |
| 全名 | cell division cycle 5-like |
| 背景介绍 | The protein encoded by this gene shares a significant similarity with Schizosaccharomyces pombe cdc5 gene product, which is a cell cycle regulator important for G2/M transition. This protein has been demonstrated to act as a positive regulator of cell cycle G2/M progression. It was also found to be an essential component of a non-snRNA spliceosome, which contains at least five additional protein factors and is required for the second catalytic step of pre-mRNA splicing. [provided by RefSeq, Jul 2008] |
| 生物功能 | DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR). [UniProt] |
| 研究领域 | Gene Regulation antibody |
| 预测分子量 | 92 kDa |
| 翻译后修饰 | Phosphorylated on serine and threonine residues. Phosphorylation on Thr-411 and Thr-438 is required for CDC5L-mediated mRNA splicing. Has no effect on subcellular location nor on homodimerization. Phosphorylated in vitro by CDK2. Phosphorylation enhances interaction with PPP1R8. |
检测图片 (1) Click the Picture to Zoom In
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ARG55057 anti-CDC5L antibody WB image
Western blot: Mouse testis and SW480 cell lysate stained with ARG55057 anti-CDC5L antibody.
