ARG42586
anti-CD79b antibody
anti-CD79b antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes CD79b |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | CD79b |
| 抗原物种 | Human |
| 抗原 | Recombinant protein corresponding to A29-E229 of Human CD79b. |
| 偶联标记 | Un-conjugated |
| 別名 | B29; B-cell-specific glycoprotein B29; Ig-beta; B-cell antigen receptor complex-associated protein beta chain; Immunoglobulin-associated B29 protein; AGM6; IGB; CD antigen CD79b |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 实际分子量 | 38 ~ 45 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | 0.2% Na2HPO4, 0.9% NaCl, 0.05% Sodium azide and 5% BSA. |
| 抗菌剂 | 0.05% Sodium azide |
| 稳定剂 | 5% BSA |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # P15530 Mouse B-cell antigen receptor complex-associated protein beta chain Swiss-port # P40259 Human B-cell antigen receptor complex-associated protein beta chain |
|---|---|
| 基因名称 | CD79B |
| 全名 | CD79b molecule, immunoglobulin-associated beta |
| 背景介绍 | The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008] |
| 生物功能 | Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation. [UniProt] |
| 细胞定位 | Cell membrane; Single-pass type I membrane protein. Note=Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts. [UniProt] |
| 预测分子量 | 26 kDa |
| 翻译后修饰 | Phosphorylated on tyrosine upon B-cell activation by SRC-type Tyr-kinases such as BLK, LYN and SYK. [UniProt] |
检测图片 (5) Click the Picture to Zoom In
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ARG42586 anti-CD79b antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Mouse spleen tissue stained with ARG42586 anti-CD79b antibody.
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ARG42586 anti-CD79b antibody WB image
Western blot: 0.5 ng of Human CD79b recombinant protein stained with ARG42586 anti-CD79b antibody at 0.5 µg/ml dilution.
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ARG42586 anti-CD79b antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Rat spleen tissue stained with ARG42586 anti-CD79b antibody.
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ARG42586 anti-CD79b antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human tonsil tissue stained with ARG42586 anti-CD79b antibody.
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ARG42586 anti-CD79b antibody WB image
Western blot: 40 µg of Raji, HL-60 and HuT whole cell lysates stained with ARG42586 anti-CD79b antibody at 0.5 µg/ml dilution.
