ARG10510
anti-CD71 / Transferrin Receptor (soluble) antibody [13E4]
anti-CD71 / Transferrin Receptor (soluble) antibody [13E4] for ELISA,Western blot and Human
Cancer antibody; Cell Biology and Cellular Response antibody; Developmental Biology antibody; Immune System antibody; Metabolism antibody
概述
| 产品描述 | Mouse Monoclonal antibody [13E4] recognizes CD71 / Transferrin Receptor (soluble) |
|---|---|
| 反应物种 | Hu |
| 应用 | ELISA, WB |
| 特异性 | Human soluble transferrin receptor and complex between soluble transferrin receptor and transferrin |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | 13E4 |
| 同位型 | IgG2a |
| 靶点名称 | CD71 / Transferrin Receptor (soluble) |
| 抗原物种 | Human |
| 抗原 | Balb/c mice immunized with purified human soluble transferrin receptor. |
| 偶联标记 | Un-conjugated |
| 別名 | TFR1; CD antigen CD71; CD71; T9; p90; TR; Trfr; Transferrin receptor protein 1; TRFR; sTfR; TfR1; TfR; TFR |
应用说明
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
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属性
| 形式 | Liquid |
|---|---|
| 纯化 | Protein A affinity purified. |
| 缓冲液 | PBS (pH 7.2) and 0.1% Sodium azide |
| 抗菌剂 | 0.1 % Sodium azide |
| 浓度 | 1.0-2.0 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | TFRC |
| 全名 | transferrin receptor |
| 生物功能 | Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. [UniProt] |
| 产品亮点 | Related Antibody Duos and Panels: ARG30200 Transferrin Receptor ELISA Antibody Duo Related products: CD71 antibodies; CD71 ELISA Kits; CD71 Duos / Panels; Anti-Mouse IgG secondary antibodies; |
| 研究领域 | Cancer antibody; Cell Biology and Cellular Response antibody; Developmental Biology antibody; Immune System antibody; Metabolism antibody |
| 预测分子量 | 85 kDa |
| 翻译后修饰 | N- and O-glycosylated, phosphorylated and palmitoylated. The serum form is only glycosylated. Proteolytically cleaved on Arg-100 to produce the soluble serum form (sTfR). Palmitoylated on both Cys-62 and Cys-67. Cys-62 seems to be the major site of palmitoylation. |
克隆号文献
A human blood-brain barrier transcytosis assay reveals antibody transcytosis influenced by pH-dependent receptor binding.
TBC1D14 regulates autophagosome formation via Rab11- and ULK1-positive recycling endosomes.
