ARG67080

anti-CD63 antibody [SQab30352]

anti-CD63 antibody [SQab30352] for IHC-Formalin-fixed paraffin-embedded sections and Human

概述

产品描述 Recombinant Rabbit Monoclonal antibody [SQab30352] recognizes CD63
反应物种 Hu
应用 IHC-P
宿主 Rabbit
克隆 Monoclonal
克隆号 SQab30352
同位型 IgG
靶点名称 CD63
抗原物种 Human
抗原 Recombinant protein of Human CD63.
偶联标记 Un-conjugated
別名 CD63; CD63 Molecule; TSPAN30; ME491; MLA1; Ocular Melanoma-Associated Antigen; CD63 Antigen (Melanoma 1 Antigen); Melanoma-Associated Antigen ME491; Tetraspanin-30; Granulophysin; CD63 Antigen; Tspan-30; OMA81H; Limp1; Lysosomal-Associated Membrane Protein 3; Lysosome Integral Membrane Protein 1; Melanoma-Associated Antigen MLA1; LAMP-3

应用说明

应用建议
应用 推荐稀释比
IHC-P1:100-1:200
应用说明 IHC-P: Antigen Retrieval: Heat mediation was performed in Tris/EDTA buffer (pH 9.0).
* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

属性

形式 Liquid
纯化 Purification with Protein A.
缓冲液 PBS, 0.01% Sodium azide, 40% Glycerol and 0.05% BSA.
抗菌剂 0.01% Sodium azide
稳定剂 40% Glycerol and 0.05% BSA
存放说明 For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项 For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接

GeneID: 967 Human CD63

Swiss-port # P08962 Human CD63 antigen

基因名称 CD63
全名 CD63 Molecule
背景介绍 The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The encoded protein is a cell surface glycoprotein that is known to complex with integrins. It may function as a blood platelet activation marker. Deficiency of this protein is associated with Hermansky-Pudlak syndrome. Also this gene has been associated with tumor progression. Alternative splicing results in multiple transcript variants encoding different protein isoforms. [provided by RefSeq, Apr 2012]
生物功能 Functions as a cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli. [Uniprot]
细胞定位 Cell membrane, Endosome, Lysosome, Membrane, Secreted. [Uniprot]
预测分子量 26 kDa
翻译后修饰 Glycoprotein, Lipoprotein, Palmitate. [Uniprot]

检测图片 (1) Click the Picture to Zoom In

  • ARG67080 anti-CD63 antibody [SQab30352] IHC-P image

    Immunohistochemistry: Human prostate stained with ARG67080 anti-CD63 antibody [SQab30352].