ARG53880
anti-CD58 antibody [MEM-63] (PE)
anti-CD58 antibody [MEM-63] (PE) for Flow cytometry and Human,Pig
Immune System antibody
概述
| 产品描述 | PE-conjugated Mouse Monoclonal antibody [MEM-63] recognizes CD58 |
|---|---|
| 反应物种 | Hu, Pig |
| 应用 | FACS |
| 特异性 | The clone MEM-63 reacts with CD58 (LFA-3), a 40-70 kDa glycoprotein distributed over many tissues, leukocytes, erythrocytes, endothelial cells, epithelial cells and fibroblasts. HLDA VI; WS Code AS A047 |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | MEM-63 |
| 同位型 | IgG1 |
| 靶点名称 | CD58 |
| 抗原物种 | Human |
| 抗原 | NALM-6 human pre-B cell line |
| 偶联标记 | PE |
| 別名 | CD antigen CD58; LFA3; ag3; Lymphocyte function-associated antigen 3; Surface glycoprotein LFA-3; Ag3; LFA-3 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化说明 | The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary. |
| 缓冲液 | TBS, 15 mM Sodium azide and 0.2% (w/v) high-grade protease free BSA |
| 抗菌剂 | 15 mM Sodium azide |
| 稳定剂 | 0.2% (w/v) high-grade protease free BSA |
| 存放说明 | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # P19256 Human Lymphocyte function-associated antigen 3 |
|---|---|
| 基因名称 | CD58 |
| 全名 | CD58 molecule |
| 背景介绍 | CD58 (LFA-3) is an immunoglobulin family adhession molecule expressed by both hematopoietic and non-hematopoietic cells (often on antigen presenting cells) and serving as ligand of CD2. This interaction is important for T cell-mediated immunity. CD58 is expressed in transmembrane form and in GPI-anchored form; the later is constitutively associated with protein kinases whereas the transmembrane form activates kinase activity upon triggering. CD58 is a powerful tool for detection of minimal residual disease in acute lymphocytic leukemia, and for evaluation of liver damage related with hepatitis B. |
| 生物功能 | Ligand of the T-lymphocyte CD2 glycoprotein. This interaction is important in mediating thymocyte interactions with thymic epithelial cells, antigen-independent and -dependent interactions of T-lymphocytes with target cells and antigen-presenting cells and the T-lymphocyte rosetting with erythrocytes. In addition, the LFA-3/CD2 interaction may prime response by both the CD2+ and LFA-3+ cells. [UniProt] |
| 研究领域 | Immune System antibody |
| 预测分子量 | 28 kDa |
检测图片 (1) Click the Picture to Zoom In
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ARG53880 anti-CD58 antibody [MEM-63] (PE) FACS image
Flow Cytometry: Human peripheral blood cells stained with ARG53880 anti-CD58 antibody [MEM-63] (PE).
