ARG40910

anti-CD51 / Integrin alpha V antibody

anti-CD51 / Integrin alpha V antibody for Western blot,IHC-Formalin-fixed paraffin-embedded sections,ICC/IF,Immunoprecipitation and Human,Mouse,Rat

概述

产品描述 Rabbit Polyclonal antibody recognizes CD51 / Integrin alpha V
反应物种 Hu, Ms, Rat
应用 ICC/IF, IHC-P, IP, WB
宿主 Rabbit
克隆 Polyclonal
同位型 IgG
靶点名称 CD51 / Integrin alpha V
抗原物种 Human
抗原 Synthetic peptide derived from Human Integrin alpha V.
偶联标记 Un-conjugated
全名 integrin, alpha V
別名 CD51; VNRA; CD antigen CD51; VTNR; Vitronectin receptor subunit alpha; Integrin alpha-V; MSK8

应用说明

应用建议
应用 推荐稀释比
ICC/IF1:50 - 1:200
IHC-P1:50 - 1:200
IP1:40
WB1:500 - 1:2000
应用说明 * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
阳性对照 A549
预测分子量 116 kDa

属性

形式 Liquid
纯化 Affinity purified.
缓冲液 PBS (pH 7.4), 150 mM NaCl, 0.02% Sodium azide and 50% Glycerol.
抗菌剂 0.02% Sodium azide
稳定剂 50% Glycerol
存放说明 For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项 For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接

GeneID: 16410 Mouse ITGAV

GeneID: 3685 Human ITGAV

Swiss-port # P06756 Human Integrin alpha-V

Swiss-port # P43406 Mouse Integrin alpha-V

基因名称 ITGAV
基因全名 integrin, alpha V
背景介绍 This gene encodes a protein that is a member of the integrin superfamily. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein undergoes post-translational cleavage to yield disulfide-linked heavy and light chains that combine with multiple integrin beta chains to form different integrins. This protein has been shown to heterodimerize with beta 1, beta 3, beta 5, beta 6, and beta 8; the heterodimer of alpha v and beta 3 is the Vitronectin receptor. This protein interacts with several extracellular matrix proteins to mediate cell adhesion and may play a role in cell migration. It is proposed that this protein may regulate angiogenesis and cancer progression. Alternative splicing results in multiple transcript variants that encode different protein isoforms. Note that the integrin alpha 5 and integrin alpha V chains are produced by distinct genes. [provided by RefSeq, Jan 2015]
生物功能 The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. [UniProt]
细胞定位 Membrane; Single-pass type I membrane protein. Cell junction, focal adhesion. [UniProt]

检测图片 (1) Click the Picture to Zoom In

  • ARG40910 anti-CD51 / Integrin alpha V antibody WB image

    Western blot: A549 cell lysate stained with ARG40910 anti-CD51 / Integrin alpha V antibody.