ARG21382

anti-CD51 / Integrin alpha V antibody [13C2] (FITC)

anti-CD51 / Integrin alpha V antibody [13C2] (FITC) for Flow cytometry,IHC-Frozen sections,ICC/IF,ELISA,Purification,Depletion,Blocking and Human,African green monkey,Rabbit,Bovine

概述

产品描述 FITC-conjugated Mouse Monoclonal antibody [13C2] recognizes CD51 / Integrin alpha V
反应物种 Hu, AGMK, Bov, Rb
应用 BL, Depletion, ELISA, FACS, ICC/IF, IHC-Fr, Puri
特异性 Human/African Green Monkey/Rabbit/Bovine CD51.
宿主 Mouse
克隆 Monoclonal
克隆号 13C2
同位型 IgG1, kappa
靶点名称 CD51 / Integrin alpha V
抗原物种 Human
抗原 Cell suspension containing osteoclasts from osteoclastomas
偶联标记 FITC
全名 integrin, alpha V
別名 CD51; VNRA; CD antigen CD51; VTNR; Vitronectin receptor subunit alpha; Integrin alpha-V; MSK8

应用说明

应用建议
应用 推荐稀释比
BLAssay-dependent
DepletionAssay-dependent
ELISAAssay-dependent
FACS10 µl/10^6 cells
ICC/IFAssay-dependent
IHC-FrAssay-dependent
PuriAssay-dependent
应用说明 * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
预测分子量 116 kDa

属性

形式 Liquid
缓冲液 PBS and Sodium azide
抗菌剂 Sodium azide
存放说明 Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项 For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接

GeneID: 281875 Bovine ITGAV

GeneID: 3685 Human ITGAV

Swiss-port # P06756 Human Integrin alpha-V

Swiss-port # P80746 Bovine Integrin alpha-V

基因名称 ITGAV
基因全名 integrin, alpha V
背景介绍 This gene encodes a protein that is a member of the integrin superfamily. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein undergoes post-translational cleavage to yield disulfide-linked heavy and light chains that combine with multiple integrin beta chains to form different integrins. This protein has been shown to heterodimerize with beta 1, beta 3, beta 5, beta 6, and beta 8; the heterodimer of alpha v and beta 3 is the Vitronectin receptor. This protein interacts with several extracellular matrix proteins to mediate cell adhesion and may play a role in cell migration. It is proposed that this protein may regulate angiogenesis and cancer progression. Alternative splicing results in multiple transcript variants that encode different protein isoforms. Note that the integrin alpha 5 and integrin alpha V chains are produced by distinct genes. [provided by RefSeq, Jan 2015]
生物功能 The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. [UniProt]