ARG23083
anti-CD49d / LPAM1 / Integrin alpha 4 antibody [HP2/1]
anti-CD49d / LPAM1 / Integrin alpha 4 antibody [HP2/1] for Flow cytometry,Functional study,IHC-Frozen sections,Immunoprecipitation and Human,Rat,Bovine,Cat,Goat,Horse,Pig,Rhesus Monkey,Rabbit
概述
| 产品描述 | Mouse Monoclonal antibody [HP2/1] recognizes CD49d / LPAM1 / Integrin alpha 4 |
|---|---|
| 反应物种 | Hu, Rat, Bov, Cat, Goat, Hrs, Pig, R. Mk, Rb |
| 应用 | FACS, FuncSt, IHC-Fr, IP |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | HP2/1 |
| 同位型 | IgG1 |
| 靶点名称 | CD49d / LPAM1 / Integrin alpha 4 |
| 抗原物种 | Human |
| 抗原 | JM leukaemia line. |
| 偶联标记 | Un-conjugated |
| 別名 | CD49 antigen-like family member D; VLA-4 subunit alpha; CD49D; Integrin alpha-IV; CD antigen CD49d; Integrin alpha-4; IA4 |
应用说明
| 应用建议 |
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| 应用说明 | Functional study: This product contains sodium azide, removal by dialysis is recommended prior to use in functional assays. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purified |
| 缓冲液 | PBS and 0.09% Sodium azide |
| 抗菌剂 | 0.09% Sodium azide |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | ITGA4 |
| 全名 | integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) |
| 背景介绍 | The product of this gene belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an alpha 4 chain. Unlike other integrin alpha chains, alpha 4 neither contains an I-domain, nor undergoes disulfide-linked cleavage. Alpha 4 chain associates with either beta 1 chain or beta 7 chain. [provided by RefSeq, Jul 2008] |
| 生物功能 | Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells. [UniProt] |
| 预测分子量 | 115 kDa |
| 翻译后修饰 | Phosphorylation on Ser-1027 inhibits PXN binding. |
