ARG65451

anti-CD42a antibody [GR-P] (FITC)

Datasheet

订购信息

包装

价格 (USD)

50 tests

335

arigo in CHINA:
恩瑞科生物
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0571-8708-1890

概述

产品描述	FITC-conjugated Mouse Monoclonal antibody [GR-P] recognizes CD42a
反应物种	Hu, Dog
应用	FACS
特异性	The clone GR-P (also known as GRP-P) recognizes CD42a (glycoprotein 9), a 22 kDa transmembrane protein constitutively expressed on megakaryocytes and platelets. HLDA IV.; WS Code P 35
宿主	Mouse
克隆	Monoclonal
克隆号	GR-P
同位型	IgG1
靶点名称	CD42a
抗原物种	Human
抗原	Human acute lymphoblastic leukemia cells
偶联标记	FITC
別名	Glycoprotein 9; CD antigen CD42a; CD42a; GPIX; GP-IX; Platelet glycoprotein IX

应用说明

应用建议

应用	推荐稀释比
FACS	4 µl / 10^6 cells

应用说明

* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

属性

形式	Liquid
纯化说明	The purified antibody is conjugated with Fluorescein isothiocyanate (FITC) under optimum conditions. The reagent is free of unconjugated FITC and adjusted for direct use. No reconstitution is necessary.
缓冲液	PBS, 15 mM Sodium azide and 0.2% (w/v) high-grade protease free BSA
抗菌剂	15 mM Sodium azide
稳定剂	0.2% (w/v) high-grade protease free BSA
存放说明	Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 2815 Human GP9 Swiss-port # P14770 Human Platelet glycoprotein IX
基因名称	GP9
全名	glycoprotein IX (platelet)
背景介绍	CD42a, also known as Glycoprotein 9 (GPIX), composes together with GPIb alpha, GPIb beta and GPV the GPIb-IX-V receptor complex critical in the process of platelet-rich thrombus formation by tethering the platelet to a thrombogenic surface. CD42b binds to von Willebrand factor (VWF) exposed at a site of vascular injury, as well as to thrombin, coagulation factors XI and XII, high molecular wight kininogen, TSP-1, integrin Mac-1 and P-selectin. Defects in the gene encoding CD42a are a cause of Bernard-Soulier syndrome, also known as giant platelet disease. These patients have unusually large platelets and have a clinical bleeding tendency.
生物功能	The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis. GP-IX may provide for membrane insertion and orientation of GP-Ib. [UniProt]
研究领域	Immune System antibody
预测分子量	19 kDa

检测图片 (2) Click the Picture to Zoom In

ARG65451 anti-CD42a antibody [GR-P] (FITC) FACS image

Flow Cytometry: Human peripheral whole blood stained with ARG65451 anti-CD42a antibody [GR-P] (FITC) (4 µl reagent / 100 µl of peripheral whole blood).
ARG65451 anti-CD42a antibody [GR-P] (FITC) FACS image

Flow Cytometry: Separation of human thrombocytes (red-filled) from neutrophil granulocytes (black-dashed). Human peripheral whole blood stained with ARG65451 anti-CD42a antibody [GR-P] (FITC) (4 µl reagent / 100 µl of peripheral whole blood).