ARG65450
anti-CD42a antibody [GR-P]
anti-CD42a antibody [GR-P] for Flow cytometry and Human,Dog
Immune System antibody
概述
| 产品描述 | Mouse Monoclonal antibody [GR-P] recognizes CD42a |
|---|---|
| 反应物种 | Hu, Dog |
| 应用 | FACS |
| 特异性 | The mouse monoclonal antibody GRP (also known as GRPP) recognizes CD42a (glycoprotein 9), a 22 kDa transmembrane protein constitutively expressed on megakaryocytes and platelets. HLDA IV.; WS Code P 35 |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | GR-P |
| 同位型 | IgG1 |
| 靶点名称 | CD42a |
| 抗原物种 | Human |
| 抗原 | Human acute lymphoblastic leukemia cells |
| 偶联标记 | Un-conjugated |
| 別名 | Glycoprotein 9; CD antigen CD42a; CD42a; GPIX; GP-IX; Platelet glycoprotein IX |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purified from cell culture supernatant by protein-A affinity chromatography. |
| 纯度 | > 95% (by SDS-PAGE) |
| 缓冲液 | PBS (pH 7.4) and 15 mM Sodium azide |
| 抗菌剂 | 15 mM Sodium azide |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | GP9 |
| 全名 | glycoprotein IX (platelet) |
| 背景介绍 | CD42a, also known as Glycoprotein 9 (GPIX), composes together with GPIb alpha, GPIb beta and GPV the GPIb-IX-V receptor complex critical in the process of platelet-rich thrombus formation by tethering the platelet to a thrombogenic surface. CD42b binds to von Willebrand factor (VWF) exposed at a site of vascular injury, as well as to thrombin, coagulation factors XI and XII, high molecular wight kininogen, TSP-1, integrin Mac-1 and P-selectin. Defects in the gene encoding CD42a are a cause of Bernard-Soulier syndrome, also known as giant platelet disease. These patients have unusually large platelets and have a clinical bleeding tendency. |
| 生物功能 | The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis. GP-IX may provide for membrane insertion and orientation of GP-Ib. [UniProt] |
| 研究领域 | Immune System antibody |
| 预测分子量 | 19 kDa |
检测图片 (2) Click the Picture to Zoom In
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ARG65450 anti-CD42a antibody [GR-P] FACS image
Flow Cytometry: Human peripheral blood stained with ARG65450 anti-CD42a antibody [GR-P] at 1 µg/ml dilution, followed by PE-conjugated Goat anti-Mouse antibody.
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ARG65450 anti-CD42a antibody [GR-P] FACS image
Flow Cytometry: Separation of human thrombocytes (red-filled) from CD42a negative lymphocytes (black-dashed). Human peripheral whole blood stained with ARG65450 anti-CD42a antibody [GR-P] at 1 µg/ml dilution, followed by PE-conjugated Goat anti-Mouse antibody.
克隆号文献
High-dose aspirin is required to influence plasma fibrin network structure in patients with type 1 diabetes.
FACS / Human
