ARG21295

anti-CD4 antibody [RFT4]

anti-CD4 antibody [RFT4] for Flow cytometry,IHC-Frozen sections,ICC/IF,Western blot and Human

Overview

Product Description Mouse Monoclonal antibody [RFT4] recognizes CD4
Tested Reactivity Hu
Tested Application FACS, ICC/IF, IHC-Fr, WB
Specificity Human CD4.
Host Mouse
Clonality Monoclonal
Clone RFT4
Isotype IgG1κ
Target Name CD4
Antigen Species Human
Immunogen Thymocytes and E-rosetted lymphocytes
Conjugation Un-conjugated
Full Name CD4 molecule
Alternate Names CD4mut; CD antigen CD4; T-cell surface glycoprotein CD4; T-cell surface antigen T4/Leu-3

Application Instructions

Application Suggestion
Application Dilution
FACS< 1 µg/10^6 cells
ICC/IFAssay-dependent
IHC-FrAssay-dependent
WBAssay-dependent
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Buffer BBS (pH 8.2)
Concentration 0.1 mg/ml
Storage instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database links

GeneID: 920 Human CD4

Swiss-port # P01730 Human T-cell surface glycoprotein CD4

Gene Symbol CD4
Gene Full Name CD4 molecule
Background This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Aug 2010]
Function Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts. [UniProt]
Highlight Related products:
CD4 antibodies; CD4 ELISA Kits; CD4 Duos / Panels; Anti-Mouse IgG secondary antibodies;
Related news:
Lymphoma
PTM Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts.