ARG41443
anti-CD3D antibody
anti-CD3D antibody for Flow cytometry,ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Immunoprecipitation,Western blot and Human
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes CD3D |
|---|---|
| 反应物种 | Hu |
| 应用 | FACS, ICC/IF, IHC-P, IP, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | CD3D |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide of Human CD3D. |
| 偶联标记 | Un-conjugated |
| 別名 | CD3D; CD3 Delta Subunit Of T-Cell Receptor Complex; T-Cell Surface Glycoprotein CD3 Delta Chain; CD3-DELTA; CD3DELTA; T3D; CD3d Antigen, Delta Polypeptide (TiT3 Complex); CD3d Molecule, Delta (CD3-TCR Complex); T-Cell Receptor T3 Delta Chain; CD3 Antigen, Delta Subunit; OKT3, Delta Chain; CD3d Molecule; CD3d Antigen; CD3 Delta; IMD19 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||||||
| 阳性对照 | Jurkat | ||||||||||||
| 实际分子量 | ~ 19 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.4), 150 mM NaCl, 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # P04234 Human T-cell surface glycoprotein CD3 delta chain |
|---|---|
| 基因名称 | CD3D |
| 全名 | CD3 Delta Subunit Of T-Cell Receptor Complex |
| 背景介绍 | The protein encoded by this gene is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell development and signal transduction. The encoded membrane protein represents the delta subunit of the CD3 complex, and along with four other CD3 subunits, binds either TCR alpha/beta or TCR gamma/delta to form the TCR/CD3 complex on the surface of T-cells. Defects in this gene are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (SCIDBNK). Two transcript variants encoding different isoforms have been found for this gene. Other variants may also exist, but the full-length natures of their transcripts has yet to be defined. |
| 生物功能 | Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. |
| 细胞定位 | Cell membrane, Membrane |
| 产品亮点 | Related products: CD3 antibodies; CD3 ELISA Kits; CD3 Duos / Panels; Anti-Rabbit IgG secondary antibodies; Related news: New antibody panels and duos for Tumor immune microenvironment Tumor-Infiltrating Lymphocytes (TILs) |
| 预测分子量 | 19 kDa |
| 翻译后修饰 | Disulfide bond, Glycoprotein, Phosphoprotein |
检测图片 (3) Click the Picture to Zoom In
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ARG41443 anti-CD3D antibody ICC/IF image
Immunofluorescence: Jurkat cells stained with ARG41443 anti-CD3D antibody.
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ARG41443 anti-CD3D antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human spleen tissue stained with ARG41443 anti-CD3D antibody.
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ARG41443 anti-CD3D antibody WB image
Western blot: Jurkat cell lysate stained with ARG41443 anti-CD3D antibody.
