ARG67246
anti-CD3 antibody [SQab30364]
anti-CD3 antibody [SQab30364] for IHC-Formalin-fixed paraffin-embedded sections and Human
概述
| 产品描述 | Rabbit Monoclonal antibody [SQab30364] recognizes CD3. |
|---|---|
| 反应物种 | Hu |
| 应用 | IHC-P |
| 宿主 | Rabbit |
| 克隆 | Monoclonal |
| 克隆号 | SQab30364 |
| 同位型 | IgG |
| 靶点名称 | CD3 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide corresponding to Human CD3E(a.a. 1-100). |
| 偶联标记 | Un-conjugated |
| 別名 | CD3E; CD3 Epsilon Subunit Of T-Cell Receptor Complex; T-Cell Surface Glycoprotein CD3 Epsilon Chain; CD3-Epsilon; CD3epsilon; CD3e Antigen, Epsilon Polypeptide (TiT3 Complex); T-Cell Surface Antigen T3/Leu-4 Epsilon Chain; CD3e Molecule, Epsilon (CD3-TCR Complex); T3E; T-Cell Antigen Receptor Complex, Epsilon Subunit Of T3; CD3e Molecule; CD3e Antigen; IMD18; TCRE |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein A. |
| 缓冲液 | PBS, 0.01% Sodium azide, 40% Glycerol and 0.05% BSA. |
| 抗菌剂 | 0.01% Sodium azide |
| 稳定剂 | 40% Glycerol and 0.05% BSA |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # P07766 Human T-cell surface glycoprotein CD3 epsilon chain |
|---|---|
| 基因名称 | CD3E |
| 全名 | CD3 Epsilon Subunit Of T-Cell Receptor Complex |
| 背景介绍 | The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. [provided by RefSeq, Jul 2008] |
| 生物功能 | In addition to its role as a TCR coreceptor, it serves as a receptor for ITPRIPL1. Ligand recognition inhibits T-cell activation by promoting interaction with NCK1, which prevents CD3E-ZAP70 interaction and blocks the ERK-NFkB signaling cascade and calcium influx. [Uniprot] |
| 细胞定位 | Cell membrane, Membrane. [Uniprot] |
| 预测分子量 | 21 kDa |
| 翻译后修饰 | Disulfide bond, Phosphoprotein. [Uniprot] |
检测图片 (2) Click the Picture to Zoom In
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ARG67246 anti-CD3 antibody [SQab30364] IHC-P image
Immunohistochemistry: Human Tonsil stained with ARG67246 anti-CD3 antibody [SQab30364] at 1:100 dilution.
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ARG67246 anti-CD3 antibody [SQab30364] IHC-P image
Immunohistochemistry: Human Appendix stained with ARG67246 anti-CD3 antibody [SQab30364] at 1:100 dilution.
