ARG58111
anti-CD278 / ICOS antibody
anti-CD278 / ICOS antibody for ELISA,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes CD278 / ICOS |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | ELISA, IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | CD278 / ICOS |
| 抗原物种 | Mouse |
| 抗原 | Recombinant protein corresponding to aa. E21-S200 of Mouse CD278 / ICOS. |
| 偶联标记 | Un-conjugated |
| 別名 | CD antigen CD278; CD278; Inducible T-cell costimulator; AILIM; Activation-inducible lymphocyte immunomediatory molecule; CVID1 |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|---|---|---|---|
| 应用说明 | IHC-P: Antigen Retrieval: Steam tissue section in Citrate buffer (pH 6.0) for 10-20 min followed by cooling at RT. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | PBS, 0.025% Sodium azide and 2% Trehalose. |
| 抗菌剂 | 0.025% Sodium azide |
| 稳定剂 | 2% Trehalose |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | ICOS |
| 全名 | inducible T-cell co-stimulator |
| 背景介绍 | The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation. [provided by RefSeq, Jul 2008] |
| 生物功能 | Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (By similarity). [UniProt] |
| 预测分子量 | 23 kDa |
| 翻译后修饰 | N-glycosylated. [UniProt] |
检测图片 (4) Click the Picture to Zoom In
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ARG58111 anti-CD278 / ICOS antibody IHC-P image
Immunohistochemistry: Formalin-fixed and paraffin-embedded Mouse spleen tissue stained with ARG58111 anti-CD278 / ICOS antibody at 1 µg/ml. Antigen Retrieval: Steam tissue section in Citrate buffer (pH 6.0) for 10-20 min followed by cooling at RT.
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ARG58111 anti-CD278 / ICOS antibody WB image
Western blot: 1) Mouse stomach, 2) Mouse spleen, 3) Mouse thymus, 4) Mouse small intestine, 5) Rat thymus and 6) Human placental lysate stained with ARG58111 anti-CD278 / ICOS antibody at 0.5 µg/ml dilution.
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ARG58111 anti-CD278 / ICOS antibody IHC-P image
Immunohistochemistry: Formalin-fixed and paraffin-embedded Mouse thymus tissue stained with ARG58111 anti-CD278 / ICOS antibody at 1 µg/ml. Antigen Retrieval: Steam tissue section in Citrate buffer (pH 6.0) for 20 min followed by cooling at RT.
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ARG58111 anti-CD278 / ICOS antibody IHC-P image
Immunohistochemistry: Formalin-fixed and paraffin-embedded Rat spleen tissue stained with ARG58111 anti-CD278 / ICOS antibody at 1 µg/ml. Antigen Retrieval: Steam tissue section in Citrate buffer (pH 6.0) for 20 min followed by cooling at RT.
