ARG58076
anti-CD278 / ICOS antibody
anti-CD278 / ICOS antibody for ICC/IF,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes CD278 / ICOS |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | ICC/IF, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | CD278 / ICOS |
| 抗原物种 | Human |
| 抗原 | Recombinant fusion protein corresponding to aa. 21-140 of Human CD278 / ICOS (NP_036224.1). |
| 偶联标记 | Un-conjugated |
| 別名 | CD antigen CD278; CD278; Inducible T-cell costimulator; AILIM; Activation-inducible lymphocyte immunomediatory molecule; CVID1 |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | Rat lung | ||||||
| 实际分子量 | 26 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | ICOS |
| 全名 | inducible T-cell co-stimulator |
| 背景介绍 | The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation. [provided by RefSeq, Jul 2008] |
| 生物功能 | Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (By similarity). [UniProt] |
| 细胞定位 | Cell membrane, Single-pass type I membrane protein, Secreted. [UniProt] |
| 预测分子量 | 23 kDa |
| 翻译后修饰 | N-glycosylated. [UniProt] |
检测图片 (2) Click the Picture to Zoom In
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ARG58076 anti-CD278 / ICOS antibody ICC/IF image
Immunofluorescence: MCF-7 cells stained with ARG58076 anti-CD278 / ICOS antibody.
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ARG58076 anti-CD278 / ICOS antibody WB image
Western blot: 25 µg of Rat lung lysate stained with ARG58076 anti-CD278 / ICOS antibody at 1:1000 dilution.
