ARG42339
anti-CD273 / PD-L2 antibody [24F.10C12] (PE)
anti-CD273 / PD-L2 antibody [24F.10C12] (PE) for Flow cytometry and Human
概述
| 产品描述 | PE-conjugated Mouse Monoclonal antibody [24F.10C12] recognizes CD273 / PD-L2 |
|---|---|
| 反应物种 | Hu |
| 应用 | FACS |
| 特异性 | The mouse monoclonal antibody 24F.10C12 recognizes an extracellular epitope of CD273 / PD-L2 (also known as B7-DC), a 25 kDa type I transmembrane protein expressed by dendritic cells, activated monocytes and T cells, heart, first trimester placenta, lung and liver, as well as in Hodgkin´s lymphoma cells and primary mediastinal B cell lymphoma (PMBL). |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | 24F.10C12 |
| 同位型 | IgG2a, kappa |
| 靶点名称 | CD273 / PD-L2 |
| 抗原物种 | Human |
| 抗原 | Human CD273. |
| 偶联标记 | PE |
| 別名 | B7DC; bA574F11.2; PDL2; CD antigen CD273; PD-L2; Programmed cell death 1 ligand 2; CD273; Btdc; PDCD1L2; Programmed death ligand 2; Butyrophilin B7-DC; B7-DC; PD-1 ligand 2; PDCD1 ligand 2 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purified |
| 缓冲液 | PBS and 15 mM Sodium azide. |
| 抗菌剂 | 15 mM Sodium azide |
| 存放说明 | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | PDCD1LG2 |
| 全名 | programmed cell death 1 ligand 2 |
| 生物功能 | Involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production (By similarity). [UniProt] |
| 细胞定位 | Isoform 3: Secreted. Isoform 2: Endomembrane system; Single-pass type I membrane protein. Isoform 1: Cell membrane; Single-pass type I membrane protein. [UniProt] |
| 预测分子量 | 31 kDa |
检测图片 (3) Click the Picture to Zoom In
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ARG42339 anti-CD273 / PD-L2 antibody [24F.10C12] (PE) FACS image
Flow Cytometry: Human GM-CSF and IL-4 stimulated peripheral blood mononuclear cells stained with ARG42339 anti-CD273 / PD-L2 antibody [24F.10C12] (PE) at 10 µl / 10^6 cells in 100 µl of cell suspension.
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ARG42339 anti-CD273 / PD-L2 antibody [24F.10C12] (PE) FACS image
Flow Cytometry: Human GM-CSF and IL-4 stimulated peripheral blood mononuclear cells stained with ARG42339 anti-CD273 / PD-L2 antibody [24F.10C12] (PE) at 10 µl / 10^6 cells in 100 µl of cell suspension and ARG53761 anti-CD11c antibody [BU15] (APC) at 10 µl / 100 µl of peripheral whole blood.
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ARG42339 anti-CD273 / PD-L2 antibody [24F.10C12] (PE) FACS image
Flow Cytometry: Separation of Human CD273 positive CD11c positive cells (red-filled) from CD273 negative CD11c negative cells (black-dashed). Human GM-CSF and IL-4 stimulated peripheral blood mononuclear cells stained with ARG42339 anti-CD273 / PD-L2 antibody [24F.10C12] (PE) at 10 µl / 10^6 cells in 100 µl of cell suspension.
